Expression plasticity of Phlebotomus papatasi salivary gland genes in distinct ecotopes through the sand fly season

BACKGROUND: Sand fly saliva can drive the outcome of Leishmania infection in animal models, and salivary components have been postulated as vaccine candidates against leishmaniasis. In the sand fly Phlebotomus papatasi, natural sugar-sources modulate the activity of proteins involved in meal digesti...

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Published in:BMC ecology 2011-10, Vol.11 (1), p.24-24, Article 24
Main Authors: Coutinho-Abreu, Iliano V, Mukbel, Rami, Hanafi, Hanafi A, Fawaz, Emad Y, El-Hossary, Shabaan S, Wadsworth, Mariha, Stayback, Gwen, Pitts, Dilkushi A, Abo-Shehada, Mahmoud, Hoel, David F, Kamhawi, Shaden, Ramalho-Ortigão, Marcelo, McDowell, Mary Ann
Format: Article
Language:English
Subjects:
Adaptation (Physiology)
Animal models
Animals
Carbohydrate Metabolism
Collections
Digestion
Disease susceptibility
disease vectors
drought
Droughts
Egypt
Environmental factors
Expression vectors
Flowers & plants
Gene expression
gene expression regulation
genes
Genes, Insect
Genetic aspects
Habitat
habitats
Hand
Human subjects
Infection
Irrigated areas
irrigated farming
Jordan
Leishmania
Leishmania - physiology
Leishmaniasis
Phlebotomus - genetics
Phlebotomus - parasitology
Phlebotomus papatasi
Plasticity
Polymerase chain reaction
Preventive medicine
Proteins
Saliva
Salivary gland
Salivary Glands
Sand
Seasons
Studies
Sugar
sugars
Tropical diseases
Up-Regulation
Vaccines
vectorial capacity
water deprivation
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cited_by cdi_FETCH-LOGICAL-b6514-de87315ed973e0fbeb0a54acb394bf66a0a34274ee67885d1188ea01728de60a3
cites cdi_FETCH-LOGICAL-b6514-de87315ed973e0fbeb0a54acb394bf66a0a34274ee67885d1188ea01728de60a3
container_end_page 24
container_issue 1
container_start_page 24
container_title BMC ecology
container_volume 11
creator Coutinho-Abreu, Iliano V
Mukbel, Rami
Hanafi, Hanafi A
Fawaz, Emad Y
El-Hossary, Shabaan S
Wadsworth, Mariha
Stayback, Gwen
Pitts, Dilkushi A
Abo-Shehada, Mahmoud
Hoel, David F
Kamhawi, Shaden
Ramalho-Ortigão, Marcelo
McDowell, Mary Ann
description BACKGROUND: Sand fly saliva can drive the outcome of Leishmania infection in animal models, and salivary components have been postulated as vaccine candidates against leishmaniasis. In the sand fly Phlebotomus papatasi, natural sugar-sources modulate the activity of proteins involved in meal digestion, and possibly influence vectorial capacity. However, only a handful of studies have assessed the variability of salivary components in sand flies, focusing on the effects of environmental factors in natural habitats. In order to better understand such interactions, we compared the expression profiles of nine P. papatasi salivary gland genes of specimens inhabiting different ecological habitats in Egypt and Jordan and throughout the sand fly season in each habitat. RESULTS: The majority of investigated genes were up-regulated in specimens from Swaymeh late in the season, when the availability of sugar sources is reduced due to water deprivation. On the other hand, these genes were not up-regulated in specimens collected from Aswan, an irrigated area less susceptible to drought effects. CONCLUSION: Expression plasticity of genes involved with vectorial capacity in disease vectors may play an important epidemiological role in the establishment of diseases in natural habitats.
doi_str_mv 10.1186/1472-6785-11-24
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In the sand fly Phlebotomus papatasi, natural sugar-sources modulate the activity of proteins involved in meal digestion, and possibly influence vectorial capacity. However, only a handful of studies have assessed the variability of salivary components in sand flies, focusing on the effects of environmental factors in natural habitats. In order to better understand such interactions, we compared the expression profiles of nine P. papatasi salivary gland genes of specimens inhabiting different ecological habitats in Egypt and Jordan and throughout the sand fly season in each habitat. RESULTS: The majority of investigated genes were up-regulated in specimens from Swaymeh late in the season, when the availability of sugar sources is reduced due to water deprivation. On the other hand, these genes were not up-regulated in specimens collected from Aswan, an irrigated area less susceptible to drought effects. 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In the sand fly Phlebotomus papatasi, natural sugar-sources modulate the activity of proteins involved in meal digestion, and possibly influence vectorial capacity. However, only a handful of studies have assessed the variability of salivary components in sand flies, focusing on the effects of environmental factors in natural habitats. In order to better understand such interactions, we compared the expression profiles of nine P. papatasi salivary gland genes of specimens inhabiting different ecological habitats in Egypt and Jordan and throughout the sand fly season in each habitat. RESULTS: The majority of investigated genes were up-regulated in specimens from Swaymeh late in the season, when the availability of sugar sources is reduced due to water deprivation. On the other hand, these genes were not up-regulated in specimens collected from Aswan, an irrigated area less susceptible to drought effects. 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1472-6785
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subjects Adaptation (Physiology)
Animal models
Animals
Carbohydrate Metabolism
Collections
Digestion
Disease susceptibility
disease vectors
drought
Droughts
Egypt
Environmental factors
Expression vectors
Flowers & plants
Gene expression
gene expression regulation
genes
Genes, Insect
Genetic aspects
Habitat
habitats
Hand
Human subjects
Infection
Irrigated areas
irrigated farming
Jordan
Leishmania
Leishmania - physiology
Leishmaniasis
Phlebotomus - genetics
Phlebotomus - parasitology
Phlebotomus papatasi
Plasticity
Polymerase chain reaction
Preventive medicine
Proteins
Saliva
Salivary gland
Salivary Glands
Sand
Seasons
Studies
Sugar
sugars
Tropical diseases
Up-Regulation
Vaccines
vectorial capacity
water deprivation
title Expression plasticity of Phlebotomus papatasi salivary gland genes in distinct ecotopes through the sand fly season
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