Prdx6 Plays a Main Role in the Crosstalk Between Aging and Metabolic Sarcopenia

With the increase in average life expectancy, several individuals are affected by age-associated non-communicable chronic diseases (NCDs). The presence of NCDs, such as type 2 diabetes mellitus (T2DM), leads to the reduction in skeletal muscle mass, a pathological condition defined as sarcopenia. A...

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Bibliographic Details
Published in:Antioxidants 2020-04, Vol.9 (4), p.329
Main Authors: Pacifici, Francesca, Della-Morte, David, Piermarini, Francesca, Arriga, Roberto, Scioli, Maria Giovanna, Capuani, Barbara, Pastore, Donatella, Coppola, Andrea, Rea, Silvia, Donadel, Giulia, Andreadi, Aikaterini, Abete, Pasquale, Sconocchia, Giuseppe, Bellia, Alfonso, Orlandi, Augusto, Lauro, Davide
Format: Article
Language:English
Subjects:
aging
diabetes mellitus
insulin resistance
peroxiredoxin6
Physiological aspects
Sarcopenia
SIRT1
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Summary:With the increase in average life expectancy, several individuals are affected by age-associated non-communicable chronic diseases (NCDs). The presence of NCDs, such as type 2 diabetes mellitus (T2DM), leads to the reduction in skeletal muscle mass, a pathological condition defined as sarcopenia. A key factor linking sarcopenia with cellular senescence and diabetes mellitus (DM) is oxidative stress. We previously reported as the absence of Peroxiredoxin 6 (Prdx6), an antioxidant enzyme implicated in maintaining intracellular redox homeostasis, induces an early-stage of T2DM. In the present study we sought to understand the role of Prdx6 in the crosstalk between aging and diabetic sarcopenia, by using Prdx6 knockout ( ) mice. Absence of Prdx6 reduced telomeres length and Sirtuin1 (SIRT1) nuclear localization. An increase in Sa-β-Gal activity and p53-p21 pro-aging pathway were also evident. An impairment in IGF-1 (Insulin-like Groth Factor-1)/Akt-1/mTOR pathway leading to a relative increase in Forkhead Box O1 (FOXO1) nuclear localization and in a decrease of muscle differentiation as per lower levels of myoblast determination protein 1 (MyoD) was observed. Muscle atrophy was also present in mice by the increase in Muscle RING finger 1 (MuRF1) levels and proteins ubiquitination associated to a reduction in muscle strength. The present study, innovatively, highlights a fundamental role of Prdx6, in the crosstalk between aging, sarcopenia, and DM.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox9040329