Parietal dysfunction during number processing in children with fetal alcohol spectrum disorders

Number processing deficits are frequently seen in children prenatally exposed to alcohol. Although the parietal lobe, which is known to mediate several key aspects of number processing, has been shown to be structurally impaired in fetal alcohol spectrum disorders (FASD), effects on functional activ...

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Bibliographic Details
Published in:NeuroImage clinical 2015-01, Vol.8 (C), p.594-605
Main Authors: Woods, K J, Meintjes, E M, Molteno, C D, Jacobson, S W, Jacobson, J L
Format: Article
Language:English
Subjects:
Child
Female
Fetal alcohol spectrum disorders
Fetal Alcohol Spectrum Disorders - physiopathology
Fetal alcohol syndrome
fMRI
Humans
Magnetic Resonance Imaging - methods
Magnitude comparison
Male
Mathematical Concepts
Number processing
Parietal
Parietal Lobe - physiopathology
Prenatal alcohol exposure
Regular
Thinking - physiology
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Summary:Number processing deficits are frequently seen in children prenatally exposed to alcohol. Although the parietal lobe, which is known to mediate several key aspects of number processing, has been shown to be structurally impaired in fetal alcohol spectrum disorders (FASD), effects on functional activity in this region during number processing have not previously been investigated. This fMRI study of 49 children examined differences in activation associated with prenatal alcohol exposure in five key parietal regions involved in number processing, using tasks involving simple addition and magnitude comparison. Despite generally similar behavioral performance, in both tasks greater prenatal alcohol exposure was related to less activation in an anterior section of the right horizontal intraparietal sulcus known to mediate mental representation and manipulation of quantity. Children with fetal alcohol syndrome and partial fetal alcohol syndrome appeared to compensate for this deficit by increased activation of the angular gyrus during the magnitude comparison task.
ISSN:2213-1582
2213-1582
DOI:10.1016/j.nicl.2015.03.023