Correlation between MMP2 expression in lung cancer tissues and clinical parameters: a retrospective clinical analysis

Background Matrix metalloproteinase 2 (MMP2) has been found to be related to malignant tumors; the aim of this study was to investigate the correlation between MMP2 expression in lung cancer tissues and clinical parameters of lung cancer. Methods The expression of MMP2 in lung cancer tissues and in...

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Published in:BMC pulmonary medicine 2020-10, Vol.20 (1), p.1-283, Article 283
Main Authors: Han, Liping, Sheng, Baowei, Zeng, Qingdi, Yao, Wei, Jiang, Qiufang
Format: Article
Language:English
Subjects:
Antibodies
Biotechnology industry
Cell growth
Development and progression
Diagnosis
Extracellular matrix
Gelatinase A
Health aspects
Histology
Immunohistochemistry
Lung cancer
Lymph nodes
Lymphatic system
Matrix metalloproteinase
Matrix metalloproteinase 2
Medical prognosis
Metalloenzymes
Metalloproteinase
Metastases
Metastasis
MMP2
Multiple regression analysis
Patients
Physiological aspects
Prognosis
Proteins
Pulmonology
Signal transduction
Statistical analysis
Survival
Tumors
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Summary:Background Matrix metalloproteinase 2 (MMP2) has been found to be related to malignant tumors; the aim of this study was to investigate the correlation between MMP2 expression in lung cancer tissues and clinical parameters of lung cancer. Methods The expression of MMP2 in lung cancer tissues and in adjacent non-malignant tissues was tested by immunohistochemistry. The correlation between the expression of MMP2 and clinical parameters of lung cancer was analyzed by Kaplan-Meier curve and multiple regression analysis. Results The expression of MMP2 was higher in lung cancer tissues than that in adjacent non-malignant tissues (p = 0.002). Increased MMP2 was associated with low differentiation (p = 0.022), tumor size (p = 0.032), lymph node metastasis (p < 0.001), advanced stage (p = 0.002). The post-surgical survival time in patients with high MMP2 expression was shorter than that in patients with low MMP2 expression (p = 0.001). High expression of MMP2 (p = 0.006) and advanced stage (p = 0.003) were independent prognostic indicators for survival of lung cancer patients. Conclusions Increased MMP2 correlates with malignant biological behavior of lung cancer and it could be a potential biomarker for diagnosis and prognosis of the disease. Keywords: Lung cancer, Matrix metalloproteinase 2, MMP2, Diagnosis, Prognosis
ISSN:1471-2466
1471-2466
DOI:10.1186/s12890-020-01317-1