Effects of Fermented Milk Containing Bifidobacterium animalis Subsp. lactis MN-Gup (MN-Gup) and MN-Gup-Based Synbiotics on Obesity Induced by High Fat Diet in Rats

Given the probiotic effects previously found in Bifidobacterium animalis subsp. lactis MN-Gup (MN-Gup) and its great application potential in dairy products, this study aimed to investigate the effects of fermented milk containing MN-Gup or MN-Gup-based synbiotics on high fat diet (HFD)-induced obes...

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Bibliographic Details
Published in:Nutrients 2022-06, Vol.14 (13), p.2631
Main Authors: Wang, Chenyuan, Li, Shusen, Sun, Erna, Xiao, Ran, Wang, Ran, Ren, Yimei, He, Jingjing, Zhang, Qi, Zhan, Jing
Format: Article
Language:English
Subjects:
Adipocytes
Bifidobacterium animalis
Bifidobacterium animalis subsp. lactis MN-Gup
Bile acids
Body weight
Body weight gain
Carbon
Cholesterol
Cytokines
Dairy products
Diet
Dyslipidemia
Fatty acids
Feces
Fermentation
Fermented milk products
Food
galacto-oligosaccharides
Galactooligosaccharides
Gastrointestinal surgery
Glucose
gut microbiota
High fat diet
Hypertrophy
Intestinal microflora
Laboratory animals
Metabolism
Metabolites
Microbiota
Microorganisms
Milk
Obesity
Oligosaccharides
Overweight
Prebiotics
Probiotics
Tumor necrosis factor-TNF
xylo-oligosaccharides
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Summary:Given the probiotic effects previously found in Bifidobacterium animalis subsp. lactis MN-Gup (MN-Gup) and its great application potential in dairy products, this study aimed to investigate the effects of fermented milk containing MN-Gup or MN-Gup-based synbiotics on high fat diet (HFD)-induced obesity in rats. Galacto-oligosaccharides (GOS) and xylo-oligosaccharides (XOS) were selected as the tested prebiotics in MN-Gup-based synbiotics due to their promotion of MN-Gup growth in vitro. After nine weeks of HFD feeding, the obese rats were intervened with fermented milk containing MN-Gup (MN-Gup FM) or its synbiotics (MN-Gup + GOS FM, MN-Gup + XOS FM) for eight weeks. The results showed that the interventions could alleviate HFD-induced body weight gain, epididymal fat deposition, adipocyte hypertrophy, dyslipidemia and inflammation, but GOS and XOS did not exhibit significant synergies with MN-Gup on those alleviations. Furthermore, the interventions could regulate the HFD-affected gut microbiota and microbial metabolites, as shown by the increases in short chain fatty acids (SCFAs) and alterations in obesity-related bile acids (BAs), which may play important roles in the mechanism underlying the alleviation of obesity. This study revealed the probiotic effects of MN-Gup on alleviating obesity and provided the basis for MN-Gup applications in the future.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14132631