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A Novel Prognostic DNA Methylation Panel for Colorectal Cancer
Colorectal cancer (CRC) is one of the most common cancers and the second leading cause of cancer-related deaths. Discrepancies in clinical outcomes are observed even among patients with same-stage CRC due to molecular heterogeneity. Thus, biomarkers for predicting prognosis in CRC patients are urgen...
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| Published in: | International journal of molecular sciences 2019-09, Vol.20 (19), p.4672 |
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| creator | Chung, Hsin-Hua Kuo, Chih-Chi Hsiao, Cheng-Wen Chen, Chao-Yang Hu, Je-Ming Hsu, Chih-Hsiung Chou, Yu-Ching Lin, Ya-Wen Shih, Yu-Lueng |
| description | Colorectal cancer (CRC) is one of the most common cancers and the second leading cause of cancer-related deaths. Discrepancies in clinical outcomes are observed even among patients with same-stage CRC due to molecular heterogeneity. Thus, biomarkers for predicting prognosis in CRC patients are urgently needed. We previously demonstrated that stage II CRC patients with
methylation had poor 5-year overall survival. However, the methylation frequency of
was only 23% in 151 pairs of CRC tissues. Thus, we aimed to develop a more robust prognostic panel for CRC using
in combination with three genes:
(
),
(
), and
(
). Through quantitative methylation analysis, we found that
,
, and
were hypermethylated in CRC tissues.
methylation was significantly associated with poor 5-year overall, and disease-free survivals in stage I and II CRC patients. Sensitivity and specificity analyses of the four-gene combination revealed the best sensitivity and optimal specificity. Moreover, patients with the four-gene methylation profile exhibited poorer disease-free survival than those without methylation. A significant effect of the four-gene methylation status on overall survival and disease-free survival was observed in early stage I and II CRC patients (
= 0.0016 and
= 0.0230, respectively). Taken together, these results demonstrate that the combination of the methylation statuses of
,
,
, and
creates a novel prognostic panel that could be considered a molecular marker for outcomes in CRC patients. |
| doi_str_mv | 10.3390/ijms20194672 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_b9f1ba77720b45d8ade4e1fbefc430af</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_b9f1ba77720b45d8ade4e1fbefc430af</doaj_id><sourcerecordid>2548658539</sourcerecordid><originalsourceid>FETCH-LOGICAL-c478t-4fe5d43d2e6409bdcbdce22962e68f7ba6b70e5bbf338d6a9c0ce1b92d2c01913</originalsourceid><addsrcrecordid>eNpdkc1LKzEUxYMo6lN3rmXAjYtXzdckk41Qqu8p-LXQdUgyN3VKOtFkKvjfG61KFQIJNz8O59yD0D7Bx4wpfNLN5plioriQdA1tE07pCGMh11feW-hPzjOMKaO12kRbjNRcEs630em4uokvEKq7FKd9zEPnqrObcXUNw-NrMEMX--rO9AXwMVWTGGICN5hQTUzvIO2iDW9Chr3Pewc9_Du_n1yMrm7_X07GVyPHZTOMuIe65aylIDhWtnXlAKVKlEHjpTXCSgy1tZ6xphVGOeyAWEVb6ko0wnbQ5VK3jWamn1I3N-lVR9Ppj0FMU21S8R5AW-WJNVJKii2v28a0wIF4C95xho0vWqdLraeFnUMx0g_JhB-iP3_67lFP44sWTfEieBE4-hRI8XkBedDzLjsIoewpLrJ-DyYElhwX9PAXOouL1JdVaVrzRtRNzVSh_i4pl2LOCfy3GYL1e8l6teSCH6wG-Ia_WmVvNY6i8w</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2548658539</pqid></control><display><type>article</type><title>A Novel Prognostic DNA Methylation Panel for Colorectal Cancer</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Chung, Hsin-Hua ; Kuo, Chih-Chi ; Hsiao, Cheng-Wen ; Chen, Chao-Yang ; Hu, Je-Ming ; Hsu, Chih-Hsiung ; Chou, Yu-Ching ; Lin, Ya-Wen ; Shih, Yu-Lueng</creator><creatorcontrib>Chung, Hsin-Hua ; Kuo, Chih-Chi ; Hsiao, Cheng-Wen ; Chen, Chao-Yang ; Hu, Je-Ming ; Hsu, Chih-Hsiung ; Chou, Yu-Ching ; Lin, Ya-Wen ; Shih, Yu-Lueng</creatorcontrib><description>Colorectal cancer (CRC) is one of the most common cancers and the second leading cause of cancer-related deaths. Discrepancies in clinical outcomes are observed even among patients with same-stage CRC due to molecular heterogeneity. Thus, biomarkers for predicting prognosis in CRC patients are urgently needed. We previously demonstrated that stage II CRC patients with
methylation had poor 5-year overall survival. However, the methylation frequency of
was only 23% in 151 pairs of CRC tissues. Thus, we aimed to develop a more robust prognostic panel for CRC using
in combination with three genes:
(
),
(
), and
(
). Through quantitative methylation analysis, we found that
,
, and
were hypermethylated in CRC tissues.
methylation was significantly associated with poor 5-year overall, and disease-free survivals in stage I and II CRC patients. Sensitivity and specificity analyses of the four-gene combination revealed the best sensitivity and optimal specificity. Moreover, patients with the four-gene methylation profile exhibited poorer disease-free survival than those without methylation. A significant effect of the four-gene methylation status on overall survival and disease-free survival was observed in early stage I and II CRC patients (
= 0.0016 and
= 0.0230, respectively). Taken together, these results demonstrate that the combination of the methylation statuses of
,
,
, and
creates a novel prognostic panel that could be considered a molecular marker for outcomes in CRC patients.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms20194672</identifier><identifier>PMID: 31547144</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Biomarkers ; Cancer ; Cancer therapies ; Chemotherapy ; Colorectal cancer ; colorectal cancer (CRC) ; Colorectal carcinoma ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Deoxyribonucleic acid ; Disease-Free Survival ; DNA ; DNA Methylation ; DNA, Neoplasm - genetics ; DNA, Neoplasm - metabolism ; Female ; Gene expression ; HCT116 Cells ; Heterogeneity ; Homeobox ; HT29 Cells ; Humans ; LIM homeobox transcription factor 1α (LMX1A) ; Male ; Medical prognosis ; Metastasis ; Neoplasm Proteins - genetics ; Neoplasm Proteins - metabolism ; Neoplasm Staging ; NK6 homeobox 1 (NKX6.1) ; Nkx6.1 protein ; Sensitivity analysis ; sex-determining region Y-box 1 (SOX1) ; Survival ; Survival analysis ; Survival Rate ; zinc finger protein 177 (ZNF177)</subject><ispartof>International journal of molecular sciences, 2019-09, Vol.20 (19), p.4672</ispartof><rights>2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-4fe5d43d2e6409bdcbdce22962e68f7ba6b70e5bbf338d6a9c0ce1b92d2c01913</citedby><cites>FETCH-LOGICAL-c478t-4fe5d43d2e6409bdcbdce22962e68f7ba6b70e5bbf338d6a9c0ce1b92d2c01913</cites><orcidid>0000-0001-6872-3684 ; 0000-0003-4629-4393 ; 0000-0002-1639-7941</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2548658539/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2548658539?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31547144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, Hsin-Hua</creatorcontrib><creatorcontrib>Kuo, Chih-Chi</creatorcontrib><creatorcontrib>Hsiao, Cheng-Wen</creatorcontrib><creatorcontrib>Chen, Chao-Yang</creatorcontrib><creatorcontrib>Hu, Je-Ming</creatorcontrib><creatorcontrib>Hsu, Chih-Hsiung</creatorcontrib><creatorcontrib>Chou, Yu-Ching</creatorcontrib><creatorcontrib>Lin, Ya-Wen</creatorcontrib><creatorcontrib>Shih, Yu-Lueng</creatorcontrib><title>A Novel Prognostic DNA Methylation Panel for Colorectal Cancer</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Colorectal cancer (CRC) is one of the most common cancers and the second leading cause of cancer-related deaths. Discrepancies in clinical outcomes are observed even among patients with same-stage CRC due to molecular heterogeneity. Thus, biomarkers for predicting prognosis in CRC patients are urgently needed. We previously demonstrated that stage II CRC patients with
methylation had poor 5-year overall survival. However, the methylation frequency of
was only 23% in 151 pairs of CRC tissues. Thus, we aimed to develop a more robust prognostic panel for CRC using
in combination with three genes:
(
),
(
), and
(
). Through quantitative methylation analysis, we found that
,
, and
were hypermethylated in CRC tissues.
methylation was significantly associated with poor 5-year overall, and disease-free survivals in stage I and II CRC patients. Sensitivity and specificity analyses of the four-gene combination revealed the best sensitivity and optimal specificity. Moreover, patients with the four-gene methylation profile exhibited poorer disease-free survival than those without methylation. A significant effect of the four-gene methylation status on overall survival and disease-free survival was observed in early stage I and II CRC patients (
= 0.0016 and
= 0.0230, respectively). Taken together, these results demonstrate that the combination of the methylation statuses of
,
,
, and
creates a novel prognostic panel that could be considered a molecular marker for outcomes in CRC patients.</description><subject>Biomarkers</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Colorectal cancer</subject><subject>colorectal cancer (CRC)</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Deoxyribonucleic acid</subject><subject>Disease-Free Survival</subject><subject>DNA</subject><subject>DNA Methylation</subject><subject>DNA, Neoplasm - genetics</subject><subject>DNA, Neoplasm - metabolism</subject><subject>Female</subject><subject>Gene expression</subject><subject>HCT116 Cells</subject><subject>Heterogeneity</subject><subject>Homeobox</subject><subject>HT29 Cells</subject><subject>Humans</subject><subject>LIM homeobox transcription factor 1α (LMX1A)</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Neoplasm Proteins - genetics</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Neoplasm Staging</subject><subject>NK6 homeobox 1 (NKX6.1)</subject><subject>Nkx6.1 protein</subject><subject>Sensitivity analysis</subject><subject>sex-determining region Y-box 1 (SOX1)</subject><subject>Survival</subject><subject>Survival analysis</subject><subject>Survival Rate</subject><subject>zinc finger protein 177 (ZNF177)</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkc1LKzEUxYMo6lN3rmXAjYtXzdckk41Qqu8p-LXQdUgyN3VKOtFkKvjfG61KFQIJNz8O59yD0D7Bx4wpfNLN5plioriQdA1tE07pCGMh11feW-hPzjOMKaO12kRbjNRcEs630em4uokvEKq7FKd9zEPnqrObcXUNw-NrMEMX--rO9AXwMVWTGGICN5hQTUzvIO2iDW9Chr3Pewc9_Du_n1yMrm7_X07GVyPHZTOMuIe65aylIDhWtnXlAKVKlEHjpTXCSgy1tZ6xphVGOeyAWEVb6ko0wnbQ5VK3jWamn1I3N-lVR9Ppj0FMU21S8R5AW-WJNVJKii2v28a0wIF4C95xho0vWqdLraeFnUMx0g_JhB-iP3_67lFP44sWTfEieBE4-hRI8XkBedDzLjsIoewpLrJ-DyYElhwX9PAXOouL1JdVaVrzRtRNzVSh_i4pl2LOCfy3GYL1e8l6teSCH6wG-Ia_WmVvNY6i8w</recordid><startdate>20190920</startdate><enddate>20190920</enddate><creator>Chung, Hsin-Hua</creator><creator>Kuo, Chih-Chi</creator><creator>Hsiao, Cheng-Wen</creator><creator>Chen, Chao-Yang</creator><creator>Hu, Je-Ming</creator><creator>Hsu, Chih-Hsiung</creator><creator>Chou, Yu-Ching</creator><creator>Lin, Ya-Wen</creator><creator>Shih, Yu-Lueng</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6872-3684</orcidid><orcidid>https://orcid.org/0000-0003-4629-4393</orcidid><orcidid>https://orcid.org/0000-0002-1639-7941</orcidid></search><sort><creationdate>20190920</creationdate><title>A Novel Prognostic DNA Methylation Panel for Colorectal Cancer</title><author>Chung, Hsin-Hua ; Kuo, Chih-Chi ; Hsiao, Cheng-Wen ; Chen, Chao-Yang ; Hu, Je-Ming ; Hsu, Chih-Hsiung ; Chou, Yu-Ching ; Lin, Ya-Wen ; Shih, Yu-Lueng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-4fe5d43d2e6409bdcbdce22962e68f7ba6b70e5bbf338d6a9c0ce1b92d2c01913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Biomarkers</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Colorectal cancer</topic><topic>colorectal cancer (CRC)</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Deoxyribonucleic acid</topic><topic>Disease-Free Survival</topic><topic>DNA</topic><topic>DNA Methylation</topic><topic>DNA, Neoplasm - genetics</topic><topic>DNA, Neoplasm - metabolism</topic><topic>Female</topic><topic>Gene expression</topic><topic>HCT116 Cells</topic><topic>Heterogeneity</topic><topic>Homeobox</topic><topic>HT29 Cells</topic><topic>Humans</topic><topic>LIM homeobox transcription factor 1α (LMX1A)</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Neoplasm Proteins - genetics</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Neoplasm Staging</topic><topic>NK6 homeobox 1 (NKX6.1)</topic><topic>Nkx6.1 protein</topic><topic>Sensitivity analysis</topic><topic>sex-determining region Y-box 1 (SOX1)</topic><topic>Survival</topic><topic>Survival analysis</topic><topic>Survival Rate</topic><topic>zinc finger protein 177 (ZNF177)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Hsin-Hua</creatorcontrib><creatorcontrib>Kuo, Chih-Chi</creatorcontrib><creatorcontrib>Hsiao, Cheng-Wen</creatorcontrib><creatorcontrib>Chen, Chao-Yang</creatorcontrib><creatorcontrib>Hu, Je-Ming</creatorcontrib><creatorcontrib>Hsu, Chih-Hsiung</creatorcontrib><creatorcontrib>Chou, Yu-Ching</creatorcontrib><creatorcontrib>Lin, Ya-Wen</creatorcontrib><creatorcontrib>Shih, Yu-Lueng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Databases</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Hsin-Hua</au><au>Kuo, Chih-Chi</au><au>Hsiao, Cheng-Wen</au><au>Chen, Chao-Yang</au><au>Hu, Je-Ming</au><au>Hsu, Chih-Hsiung</au><au>Chou, Yu-Ching</au><au>Lin, Ya-Wen</au><au>Shih, Yu-Lueng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Novel Prognostic DNA Methylation Panel for Colorectal Cancer</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2019-09-20</date><risdate>2019</risdate><volume>20</volume><issue>19</issue><spage>4672</spage><pages>4672-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Colorectal cancer (CRC) is one of the most common cancers and the second leading cause of cancer-related deaths. Discrepancies in clinical outcomes are observed even among patients with same-stage CRC due to molecular heterogeneity. Thus, biomarkers for predicting prognosis in CRC patients are urgently needed. We previously demonstrated that stage II CRC patients with
methylation had poor 5-year overall survival. However, the methylation frequency of
was only 23% in 151 pairs of CRC tissues. Thus, we aimed to develop a more robust prognostic panel for CRC using
in combination with three genes:
(
),
(
), and
(
). Through quantitative methylation analysis, we found that
,
, and
were hypermethylated in CRC tissues.
methylation was significantly associated with poor 5-year overall, and disease-free survivals in stage I and II CRC patients. Sensitivity and specificity analyses of the four-gene combination revealed the best sensitivity and optimal specificity. Moreover, patients with the four-gene methylation profile exhibited poorer disease-free survival than those without methylation. A significant effect of the four-gene methylation status on overall survival and disease-free survival was observed in early stage I and II CRC patients (
= 0.0016 and
= 0.0230, respectively). Taken together, these results demonstrate that the combination of the methylation statuses of
,
,
, and
creates a novel prognostic panel that could be considered a molecular marker for outcomes in CRC patients.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>31547144</pmid><doi>10.3390/ijms20194672</doi><orcidid>https://orcid.org/0000-0001-6872-3684</orcidid><orcidid>https://orcid.org/0000-0003-4629-4393</orcidid><orcidid>https://orcid.org/0000-0002-1639-7941</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | International journal of molecular sciences, 2019-09, Vol.20 (19), p.4672 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Biomarkers Cancer Cancer therapies Chemotherapy Colorectal cancer colorectal cancer (CRC) Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Deoxyribonucleic acid Disease-Free Survival DNA DNA Methylation DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Female Gene expression HCT116 Cells Heterogeneity Homeobox HT29 Cells Humans LIM homeobox transcription factor 1α (LMX1A) Male Medical prognosis Metastasis Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasm Staging NK6 homeobox 1 (NKX6.1) Nkx6.1 protein Sensitivity analysis sex-determining region Y-box 1 (SOX1) Survival Survival analysis Survival Rate zinc finger protein 177 (ZNF177) |
| title | A Novel Prognostic DNA Methylation Panel for Colorectal Cancer |
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