Modulation of Functional Connectivity in Response to Mirror Visual Feedback in Stroke Survivors: An MEG Study

Background. Several brain regions are activated in response to mirror visual feedback (MVF). However, less is known about how these brain areas and their connectivity are modulated in stroke patients. This study aimed to explore the effects of MVF on brain functional connectivity in stroke patients....

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Bibliographic Details
Published in:Brain sciences 2021-09, Vol.11 (10), p.1284
Main Authors: Tai, Ruei-Yi, Zhu, Jun-Ding, Chen, Chih-Chi, Hsieh, Yu-Wei, Cheng, Chia-Hsiung
Format: Article
Language:English
Subjects:
Asymmetry
Brain
coherence
Cortex (cingulate)
Cortex (motor)
Cortex (parietal)
Feedback
functional connectivity
Investigations
Magnetoencephalography
magnetoencephalography (MEG)
mirror therapy (MT)
mirror visual feedback (MVF)
Neural networks
Stroke
Visual cortex
Visual perception
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Summary:Background. Several brain regions are activated in response to mirror visual feedback (MVF). However, less is known about how these brain areas and their connectivity are modulated in stroke patients. This study aimed to explore the effects of MVF on brain functional connectivity in stroke patients. Materials and Methods. We enrolled 15 stroke patients who executed Bilateral-No mirror, Bilateral-Mirror, and Unilateral-Mirror conditions. The coherence values among five brain regions of interest in four different frequency bands were calculated from magnetoencephalographic signals. We examined the differences in functional connectivity of each two brain areas between the Bilateral-No mirror and Bilateral-Mirror conditions and between the Bilateral-Mirror and Unilateral-Mirror conditions. Results. The functional connectivity analyses revealed significantly stronger connectivity between the posterior cingulate cortex and primary motor cortex in the beta band (adjusted p = 0.04) and possibly stronger connectivity between the precuneus and primary visual cortex in the theta band (adjusted p = 0.08) in the Bilateral-Mirror condition than those in the Bilateral-No mirror condition. However, the comparisons between the Bilateral-Mirror and Unilateral-Mirror conditions revealed no significant differences in cortical coherence in all frequency bands. Conclusions. Providing MVF to stroke patients may modulate the lesioned primary motor cortex through visuospatial and attentional cortical networks.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci11101284