Aortic valve replacement in sheep with a novel trileaflet mechanical heart valve prosthesis without anticoagulationCentral MessagePerspective

Background: Even after decades of intensive research, an ideal heart valve prosthesis remains elusive. Shortcomings of conventional devices include reduced durability of bioprostheses and the thrombogenicity of mechanical substitutes, necessitating anticoagulation and resulting in imperfect hemodyna...

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Bibliographic Details
Published in:JTCVS open 2021-09, Vol.7, p.76-88
Main Authors: Tim Schaller, MSc, Michael Scharfschwerdt, PhD, Kathrin Schubert, MSc, Cornelia Prinz, PhD, Ulrich Lembke, PhD, Hans-Hinrich Sievers, MD
Format: Article
Language:English
Subjects:
animal study
anticoagulation
aortic valve replacement
mechanical heart valve
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Summary:Background: Even after decades of intensive research, an ideal heart valve prosthesis remains elusive. Shortcomings of conventional devices include reduced durability of bioprostheses and the thrombogenicity of mechanical substitutes, necessitating anticoagulation and resulting in imperfect hemodynamics. Here we present in vivo results of a novel mechanical heart valve prosthesis aiming for freedom from anticoagulation. Methods: Four female sheep had their aortic valves replaced using the novel mechanical heart valve (size 21 mm), with no postoperative anticoagulation treatment. This trileaflet heart valve was designed with the pivots in the systolic central flow. Hemodynamics, biochemistry, hematology, and macroscopy and microscopy were studied at 90 days in 2 sheep and at 1 year in the other 2 sheep. Results: Mean (
ISSN:2666-2736
2666-2736