HuR cytoplasmic expression is associated with increased cyclin A expression and poor outcome with upper urinary tract urothelial carcinoma

HuR is an RNA-binding protein that post-transcriptionally modulates the expressions of various target genes implicated in carcinogenesis, such as CCNA2 encoding cyclin A. No prior study attempted to evaluate the significance of HuR expression in a large cohort with upper urinary tract urothelial car...

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Published in:BMC cancer 2012-12, Vol.12 (1), p.611-611, Article 611
Main Authors: Liang, Peir-In, Li, Wei-Ming, Wang, Yu-Hui, Wu, Ting-Feng, Wu, Wen-Ren, Liao, Alex C, Shen, Kun-Hung, Wei, Yu-Ching, Hsing, Chung-Hsi, Shiue, Yow-Ling, Huang, Hsuan-Ying, Hsu, Han-Ping, Chen, Li-Tzon, Lin, Ching-Yih, Tai, Chein, Lin, Chun-Mao, Li, Chien-Feng
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Breast cancer
Carcinoma, Transitional Cell - metabolism
Carcinoma, Transitional Cell - pathology
Carcinoma, Transitional Cell - therapy
Chemotherapy
Cohort Studies
Cyclin A
Cyclin A - metabolism
Cytoplasm - metabolism
Disease-Free Survival
ELAV Proteins - metabolism
Female
Humans
HuR
Immunohistochemistry
Male
Medical research
Middle Aged
Multivariate Analysis
Prognosis
Proteins
Studies
Upper urinary tract urothelial carcinoma
Urologic Neoplasms - metabolism
Urologic Neoplasms - pathology
Urologic Neoplasms - therapy
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Summary:HuR is an RNA-binding protein that post-transcriptionally modulates the expressions of various target genes implicated in carcinogenesis, such as CCNA2 encoding cyclin A. No prior study attempted to evaluate the significance of HuR expression in a large cohort with upper urinary tract urothelial carcinomas (UTUCs). In total, 340 cases of primary localized UTUC without previous or concordant bladder carcinoma were selected. All of these patients received ureterectomy or radical nephroureterectomy with curative intents. Pathological slides were reviewed, and clinical findings were collected. Immunostaining for HuR and cyclin A was performed and evaluated by using H-score. The results of cytoplasmic HuR and nuclear cyclin A expressions were correlated with disease-specific survival (DSS), metastasis-free survival (MeFS), urinary bladder recurrence-free survival (UBRFS), and various clinicopathological factors. HuR cytoplasmic expression was significantly related to the pT status, lymph node metastasis, a higher histological grade, the pattern of invasion, vascular and perineurial invasion, and cyclin A expression (p = 0.005). Importantly, HuR cytoplasmic expression was strongly associated with a worse DSS (p 
ISSN:1471-2407
1471-2407
DOI:10.1186/1471-2407-12-611