Biomarker correlates of survival in pediatric patients with Ebola virus disease

Outbreaks of Ebola virus disease (EVD) occur sporadically in Africa and are associated with high case-fatality rates. Historically, children have been less affected than adults. The 2000-2001 Sudan virus-associated EVD outbreak in the Gulu district of Uganda resulted in 55 pediatric and 161 adult la...

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Bibliographic Details
Published in:Emerging infectious diseases 2014-10, Vol.20 (10), p.1683-1690
Main Authors: McElroy, Anita K, Erickson, Bobbie R, Flietstra, Timothy D, Rollin, Pierre E, Nichol, Stuart T, Towner, Jonathan S, Spiropoulou, Christina F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers
Child
Child, Preschool
Children
cytokines
Cytokines - blood
Cytokines - metabolism
Disease Outbreaks
Diseases
Ebola
Ebola hemorrhagic fever
Ebola virus
Ebola virus infections
EHF
endothelium
Female
Health aspects
Hemorrhagic Fever, Ebola - blood
Hemorrhagic Fever, Ebola - epidemiology
Hemorrhagic Fever, Ebola - mortality
Humans
Male
Patient outcomes
pediatric
Pediatrics
T cells
Uganda - epidemiology
Viremia
Virus diseases
Virus diseases in children
Young Adult
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Summary:Outbreaks of Ebola virus disease (EVD) occur sporadically in Africa and are associated with high case-fatality rates. Historically, children have been less affected than adults. The 2000-2001 Sudan virus-associated EVD outbreak in the Gulu district of Uganda resulted in 55 pediatric and 161 adult laboratory-confirmed cases. We used a series of multiplex assays to measure the concentrations of 55 serum analytes in specimens from patients from that outbreak to identify biomarkers specific to pediatric disease. Pediatric patients who survived had higher levels of the chemokine regulated on activation, normal T-cell expressed and secreted marker and lower levels of plasminogen activator inhibitor 1, soluble intracellular adhesion molecule, and soluble vascular cell adhesion molecule than did pediatric patients who died. Adult patients had similar levels of these analytes regardless of outcome. Our findings suggest that children with EVD may benefit from different treatment regimens than those for adults.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2010.140430