Faecal Short-Chain, Long-Chain, and Branched-Chain Fatty Acids as Markers of Different Chronic Inflammatory Enteropathies in Dogs

Chronic inflammatory enteropathies (CIEs) are classified based on treatment trials, and new methods are being sought for earlier differentiation and characterization. infection (GIA) is one of the first differential diagnoses and may be present in CIE-affected dogs. The aim of this study was to eval...

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Bibliographic Details
Published in:Animals (Basel) 2024-06, Vol.14 (12), p.1825
Main Authors: Higueras, Cristina, Sainz, Ángel, García-Sancho, Mercedes, Rodríguez-Franco, Fernando, Rey, Ana I
Format: Article
Language:English
Subjects:
Amino acids
Bacteria
Chronic illnesses
desaturase index
Diet
Digestive system diseases
Dogs
elongase index
Endoscopy
faecal fatty acid profile
Fatty acids
food-responsive enteropathy
gut health
Health aspects
Homeostasis
immunosuppressant-responsive enteropathy
Infections
Lipids
Membranes
Microbiota
Pancreatitis
Parasites
Proteins
Systemic diseases
Unsaturated fatty acids
Veterinary medicine
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Summary:Chronic inflammatory enteropathies (CIEs) are classified based on treatment trials, and new methods are being sought for earlier differentiation and characterization. infection (GIA) is one of the first differential diagnoses and may be present in CIE-affected dogs. The aim of this study was to evaluate the faecal characteristics and faecal fatty acid profile (short, medium, long, and branched-chain fatty acids) in dogs with food-responsive enteropathy (FRE), immunosuppressant-responsive enteropathy (IRE), and dogs infected with compared to healthy control (HC) animals as a potential non-invasive indicator of intestinal health that helps in the differentiation of CIEs. The C16:1n-7 percentage ( = 0.0001) and C16:1n-7/C16:0 ratio ( = 0.0001) served to differentiate between HC, FRE, and IRE. IRE dogs presented lower levels of short-chain fatty acids (∑SCFAs) ( = 0.0008) and acetic acid (C2) ( = 0.0007) compared to the other three groups and lower propionic acid (C3) ( = 0.0022) compared to HCs. IRE and GIA presented higher faecal fat content ( = 0.0080) and ratio of iso/anteiso branched-chain fatty acids (BCFAs) compared to HC and FRE. Correlations between some fatty acids and desaturation indices with the canine inflammatory bowel disease activity index and faecal characteristics were observed, suggesting that these compounds could play an important role in the pathogenesis of these diseases.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani14121825