Tumor alkalization therapy: misconception or good therapeutics perspective? - the case of malignant ascites

Tumor acidity has been identified as a key factor in promoting cancer progression, metastasis, and resistance. Tumor alkalization therapy has emerged as a potential strategy for cancer treatment. This article provides preclinical and clinical evidence for tumor alkalization therapy as a promising ca...

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Bibliographic Details
Published in:Frontiers in oncology 2024-02, Vol.14, p.1342802
Main Authors: Bogdanov, Alexey, Verlov, Nikolay, Bogdanov, Andrey, Burdakov, Vladimir, Semiletov, Valeriy, Egorenkov, Vitaliy, Volkov, Nikita, Moiseyenko, Vladimir
Format: Article
Language:English
Subjects:
alkalization therapy
intraperitoneal perfusion
malignant ascites
Oncology
sodium bicarbonate
tumor acidity
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Summary:Tumor acidity has been identified as a key factor in promoting cancer progression, metastasis, and resistance. Tumor alkalization therapy has emerged as a potential strategy for cancer treatment. This article provides preclinical and clinical evidence for tumor alkalization therapy as a promising cancer treatment strategy. The potential of tumor alkalization therapy using sodium bicarbonate in the treatment of malignant ascites was studied. The concept of intraperitoneal perfusion with an alkalizing solution to increase the extracellular pH and its antitumor effect were explored. The significant extension in the overall survival of the Ehrlich ascites carcinoma mice treated with sodium bicarbonate solution compared to those treated with a sodium chloride solution was observed. In the sodium bicarbonate group, mice had a median survival of 30 days after tumor cell injection, which was significantly (p
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2024.1342802