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The potential of RNA methylation in the treatment of cardiovascular diseases

RNA methylation has emerged as a dynamic regulatory mechanism that impacts gene expression and protein synthesis. Among the known RNA methylation modifications, N6-methyladenosine (m6A), 5-methylcytosine (m5C), 3-methylcytosine (m3C), and N7-methylguanosine (m7G) have been studied extensively. In pa...

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Bibliographic Details
Published in:iScience 2024-08, Vol.27 (8), p.110524, Article 110524
Main Authors: Wang, Kai, Wang, YuQin, Li, YingHui, Fang, Bo, Li, Bo, Cheng, Wei, Wang, Kun, Yang, SuMin
Format: Article
Language:English
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Summary:RNA methylation has emerged as a dynamic regulatory mechanism that impacts gene expression and protein synthesis. Among the known RNA methylation modifications, N6-methyladenosine (m6A), 5-methylcytosine (m5C), 3-methylcytosine (m3C), and N7-methylguanosine (m7G) have been studied extensively. In particular, m6A is the most abundant RNA modification and has attracted significant attention due to its potential effect on multiple biological processes. Recent studies have demonstrated that RNA methylation plays an important role in the development and progression of cardiovascular disease (CVD). To identify key pathogenic genes of CVD and potential therapeutic targets, we reviewed several common RNA methylation and summarized the research progress of RNA methylation in diverse CVDs, intending to inspire effective treatment strategies. [Display omitted] Clinical genetics; Cardiovascular medicine
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2024.110524