Activation of ChTLR15/ChNF-κB-ChNLRP3/ChIL-1β signaling transduction pathway mediated inflammatory responses to E. tenella infection

Avian coccidiosis caused by Eimeria leads to severe economic losses in the global poultry industry. Although chicken Toll-like receptor 15 (ChTLR15) was reported to be involved in Eimeria infection, the detailed mechanism underlying its role in the inflammatory response remains to be discovered. The...

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Bibliographic Details
Published in:Veterinary research (Paris) 2021-01, Vol.52 (1), p.15-15, Article 15
Main Authors: Li, Jian, Yang, Xuelian, Jia, Zhipeng, Ma, Chunli, Pan, Xinghui, Ma, Dexing
Format: Article
Language:English
Subjects:
Animal biology
ChNLRP3
ChTLR15
Drug dosages
Drug resistance
E coli
E. tenella sporozoites
Fibroblasts
Genes
Infections
Inflammatory responses
Laboratories
Life Sciences
Parasites
Pathogens
Poultry
Protein expression
Proteins
Signal transduction
Vaccines
Veterinary medicine and animal Health
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Summary:Avian coccidiosis caused by Eimeria leads to severe economic losses in the global poultry industry. Although chicken Toll-like receptor 15 (ChTLR15) was reported to be involved in Eimeria infection, the detailed mechanism underlying its role in the inflammatory response remains to be discovered. The present study demonstrated that the mRNA expression levels of ChTLR15, ChMyD88, ChNF-κB, ChNLRP3, ChCaspase-1, ChIL-18 and ChIL-1β and the protein levels of ChTLR15 and ChNLRP3 in cecal tissues of Eimeria-infected chickens were significantly elevated at 4, 12, and 24 h compared with those in noninfected control chickens (p 
ISSN:1297-9716
0928-4249
1297-9716
DOI:10.1186/s13567-020-00885-8