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pH-responsive polymer micelles for methotrexate delivery at tumor microenvironments
Methotrexate (MTX) anticancer drug was successfully loaded and released in a controlled manner from polymer micelles made of a diblock copolymer of poly(monomethoxy ethylene glycol)- -poly(ε-caprolactone) (mPEG-PCL). The empty and MTX-loaded micelles (MTX/mPEG-PCL) were characterized by electron mic...
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| Published in: | e-Polymers 2020-01, Vol.20 (1), p.624-635 |
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| creator | Carrillo-Castillo, Teresa Darlen Castro-Carmona, Javier Servando Luna-Velasco, Antonia Zaragoza-Contreras, Erasto Armando |
| description | Methotrexate (MTX) anticancer drug was successfully loaded and released in a controlled manner from polymer micelles made of a diblock copolymer of poly(monomethoxy ethylene glycol)-
-poly(ε-caprolactone) (mPEG-PCL). The empty and MTX-loaded micelles (MTX/mPEG-PCL) were characterized by electron microscopy. The drug release dependence upon pH 5.4, 6.5, and 7.4 for 30 days was proven and characterized by UV-Vis spectroscopy. The cytotoxic effect of MTX/mPEG-PCL micelles on MCF-7 breast cancer cells was evaluated through an MTT assay. The morphological analysis indicated the successful formation of micelles of 76 and 131 nm for empty and MTX-loaded micelles, respectively. An encapsulation efficiency of 70.2% and a loading capacity of 8.8% were obtained. The
release of MTX showed a gradual and sustained profile over 22 days, with a clear trend to much higher release at acidic pH (80 and 90% for pH 6.7 and 5.5, respectively). The MTX/mPEG-PCL micelles showed an IC
of MCF-7 cells at 30 µg mL
. The results suggested that MTX/mPEG-PCL could be a promising drug delivery system for cancer treatment.
pH-responsive copolymer micelles for methotrexate delivery |
| doi_str_mv | 10.1515/epoly-2020-0064 |
| format | article |
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-poly(ε-caprolactone) (mPEG-PCL). The empty and MTX-loaded micelles (MTX/mPEG-PCL) were characterized by electron microscopy. The drug release dependence upon pH 5.4, 6.5, and 7.4 for 30 days was proven and characterized by UV-Vis spectroscopy. The cytotoxic effect of MTX/mPEG-PCL micelles on MCF-7 breast cancer cells was evaluated through an MTT assay. The morphological analysis indicated the successful formation of micelles of 76 and 131 nm for empty and MTX-loaded micelles, respectively. An encapsulation efficiency of 70.2% and a loading capacity of 8.8% were obtained. The
release of MTX showed a gradual and sustained profile over 22 days, with a clear trend to much higher release at acidic pH (80 and 90% for pH 6.7 and 5.5, respectively). The MTX/mPEG-PCL micelles showed an IC
of MCF-7 cells at 30 µg mL
. The results suggested that MTX/mPEG-PCL could be a promising drug delivery system for cancer treatment.
pH-responsive copolymer micelles for methotrexate delivery</description><identifier>ISSN: 2197-4586</identifier><identifier>EISSN: 1618-7229</identifier><identifier>DOI: 10.1515/epoly-2020-0064</identifier><language>eng</language><publisher>Berlin: De Gruyter</publisher><subject>Block copolymers ; cancer treatment ; copolymer micelles ; drug delivery system ; Drug delivery systems ; encapsulation efficiency ; Ethylene glycol ; Materials science ; Methotrexate ; Micelles ; MPEG encoders ; Polymers</subject><ispartof>e-Polymers, 2020-01, Vol.20 (1), p.624-635</ispartof><rights>2020. This work is published under http://creativecommons.org/licenses/by/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-daa1aabed1c7379d8bcb3262e67554b3e8ac2c556b80f57bd4db79113d5d21113</citedby><cites>FETCH-LOGICAL-c430t-daa1aabed1c7379d8bcb3262e67554b3e8ac2c556b80f57bd4db79113d5d21113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/epoly-2020-0064/pdf$$EPDF$$P50$$Gwalterdegruyter$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/epoly-2020-0064/html$$EHTML$$P50$$Gwalterdegruyter$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,27924,27925,67158,68942</link.rule.ids></links><search><creatorcontrib>Carrillo-Castillo, Teresa Darlen</creatorcontrib><creatorcontrib>Castro-Carmona, Javier Servando</creatorcontrib><creatorcontrib>Luna-Velasco, Antonia</creatorcontrib><creatorcontrib>Zaragoza-Contreras, Erasto Armando</creatorcontrib><title>pH-responsive polymer micelles for methotrexate delivery at tumor microenvironments</title><title>e-Polymers</title><description>Methotrexate (MTX) anticancer drug was successfully loaded and released in a controlled manner from polymer micelles made of a diblock copolymer of poly(monomethoxy ethylene glycol)-
-poly(ε-caprolactone) (mPEG-PCL). The empty and MTX-loaded micelles (MTX/mPEG-PCL) were characterized by electron microscopy. The drug release dependence upon pH 5.4, 6.5, and 7.4 for 30 days was proven and characterized by UV-Vis spectroscopy. The cytotoxic effect of MTX/mPEG-PCL micelles on MCF-7 breast cancer cells was evaluated through an MTT assay. The morphological analysis indicated the successful formation of micelles of 76 and 131 nm for empty and MTX-loaded micelles, respectively. An encapsulation efficiency of 70.2% and a loading capacity of 8.8% were obtained. The
release of MTX showed a gradual and sustained profile over 22 days, with a clear trend to much higher release at acidic pH (80 and 90% for pH 6.7 and 5.5, respectively). The MTX/mPEG-PCL micelles showed an IC
of MCF-7 cells at 30 µg mL
. The results suggested that MTX/mPEG-PCL could be a promising drug delivery system for cancer treatment.
pH-responsive copolymer micelles for methotrexate delivery</description><subject>Block copolymers</subject><subject>cancer treatment</subject><subject>copolymer micelles</subject><subject>drug delivery system</subject><subject>Drug delivery systems</subject><subject>encapsulation efficiency</subject><subject>Ethylene glycol</subject><subject>Materials science</subject><subject>Methotrexate</subject><subject>Micelles</subject><subject>MPEG encoders</subject><subject>Polymers</subject><issn>2197-4586</issn><issn>1618-7229</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp1kTtPxDAQhC0EEsejpo1EHbDXr6SgQIiXhEQB1JYT70FOSRxsH3D_Ht8dgopqbGvm27WGkBNGz5hk8hwn369KoEBLSpXYITOmWFVqgHqXzIDVuhSyUvvkIMYFpcCB6Rl5mu7KgHHyY-w-sFgzBgzF0LXY9xiLuc8XTG8-BfyyCQuHfTaGVWFTkZaD33iDx_GjC34ccEzxiOzNbR_x-EcPycvN9fPVXfnweHt_dflQtoLTVDprmbUNOtZqrmtXNW3DQQEqLaVoOFa2hVZK1VR0LnXjhGt0zRh30gHLekjut1zn7cJMoRtsWBlvO7N58OHV2JC6tkfTWAW1pZnnrGipqFBxDRUopbhiSDPrdMuagn9fYkxm4ZdhzOsbEEpzoWtaZdf51pV_HGPA-e9URs26BbNpwaxbMOsWcuJim_i0fcLg8DUsV_nwh_8nCZQpEPwbESWRIw</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Carrillo-Castillo, Teresa Darlen</creator><creator>Castro-Carmona, Javier Servando</creator><creator>Luna-Velasco, Antonia</creator><creator>Zaragoza-Contreras, Erasto Armando</creator><general>De Gruyter</general><general>Walter de Gruyter GmbH</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope></search><sort><creationdate>20200101</creationdate><title>pH-responsive polymer micelles for methotrexate delivery at tumor microenvironments</title><author>Carrillo-Castillo, Teresa Darlen ; 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-poly(ε-caprolactone) (mPEG-PCL). The empty and MTX-loaded micelles (MTX/mPEG-PCL) were characterized by electron microscopy. The drug release dependence upon pH 5.4, 6.5, and 7.4 for 30 days was proven and characterized by UV-Vis spectroscopy. The cytotoxic effect of MTX/mPEG-PCL micelles on MCF-7 breast cancer cells was evaluated through an MTT assay. The morphological analysis indicated the successful formation of micelles of 76 and 131 nm for empty and MTX-loaded micelles, respectively. An encapsulation efficiency of 70.2% and a loading capacity of 8.8% were obtained. The
release of MTX showed a gradual and sustained profile over 22 days, with a clear trend to much higher release at acidic pH (80 and 90% for pH 6.7 and 5.5, respectively). The MTX/mPEG-PCL micelles showed an IC
of MCF-7 cells at 30 µg mL
. The results suggested that MTX/mPEG-PCL could be a promising drug delivery system for cancer treatment.
pH-responsive copolymer micelles for methotrexate delivery</abstract><cop>Berlin</cop><pub>De Gruyter</pub><doi>10.1515/epoly-2020-0064</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | e-Polymers, 2020-01, Vol.20 (1), p.624-635 |
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| source | Walter De Gruyter: Open Access Journals |
| subjects | Block copolymers cancer treatment copolymer micelles drug delivery system Drug delivery systems encapsulation efficiency Ethylene glycol Materials science Methotrexate Micelles MPEG encoders Polymers |
| title | pH-responsive polymer micelles for methotrexate delivery at tumor microenvironments |
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