Increased serum galectin-3 level is associated with endothelial dysfunction and cardiovascular events in patients with hypertension

Endothelial dysfunction can lead to various harmful cardiovascular complications. The importance of galectin-3 (Gal-3) has been proposed in some cardiac diseases related to chronic inflammation. However, its role in hypertension-induced endothelial dysfunction remains unclear. We enrolled 120 patien...

Full description

Saved in:
Bibliographic Details
Published in:Heliyon 2025-01, Vol.11 (1), p.e41111, Article e41111
Main Authors: Wang, Hui-Sheng, Hsu, Bang-Gee, Wang, Ji-Hung, Yang, Chiu-Fen
Format: Article
Language:English
Subjects:
Cardiovascular events
Endothelial dysfunction
Galectin-3
Hypertension
Vascular reactivity index
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Endothelial dysfunction can lead to various harmful cardiovascular complications. The importance of galectin-3 (Gal-3) has been proposed in some cardiac diseases related to chronic inflammation. However, its role in hypertension-induced endothelial dysfunction remains unclear. We enrolled 120 patients with hypertension, assessed their baseline characteristics, and monitored their 7-year cardiovascular outcomes. We performed an enzyme-linked immunosorbent assay to measure serum Gal-3 levels. The vascular reactivity index (VRI) was examined by digital thermal monitoring. Patients with VRI
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e41111