602 Childhood-onset Systemic Lupus Erythematosus: Long-term outcomes in a large multi-ethnic Ontario cohort

Background/PurposeThe long-term morbidity and mortality of childhood-onset SLE (cSLE) after transition to adult care is not well documented. The present study aims to fill this knowledge gap by analyzing outcomes in a large province-wide cSLE clinical cohort linked to multiple administrative healthc...

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Bibliographic Details
Published in:Lupus science & medicine 2022-12, Vol.9 (Suppl 3), p.A25-A26
Main Authors: Jeoung, Steve, Berard, Roberta A, Pope, Janet E, Roth, Johannes, Carter Thorne, J, Silverman, Earl D, Levy, Deborah M
Format: Article
Language:English
Subjects:
Cancer
Ethnicity
Hemodialysis
Kidney diseases
Kidney transplants
Lupus
Lupus 21st Century 2022
Minority & ethnic groups
Mortality
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Summary:Background/PurposeThe long-term morbidity and mortality of childhood-onset SLE (cSLE) after transition to adult care is not well documented. The present study aims to fill this knowledge gap by analyzing outcomes in a large province-wide cSLE clinical cohort linked to multiple administrative healthcare databases. Our objectives were to: 1) determine all-cause and cause-specific mortality rates, adverse renal event rates, cardiovascular event rates, and cancer rates in cSLE; and 2) determine baseline characteristics associated with higher rates of transition between 3 different states: event-free (entry), adverse renal event, and death.MethodsClinical data were abstracted for cSLE patients (
ISSN:2053-8790
DOI:10.1136/lupus-2022-lupus21century.23