Acute Promyelocytic Leukemia Presenting With a Myeloid Sarcoma of the Spine: A Case Report and Literature Review

Myeloid sarcoma is a rare extramedullary tumor of immature myeloid cells. Certain known acute myeloid leukemia cytogenetic abnormalities, in particular t(8,21), has been associated with a higher incidence. Myeloid sarcoma, which rarely happens in acute promyelocytic leukemias, is more common in recu...

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Bibliographic Details
Published in:Frontiers in oncology 2022-03, Vol.12, p.851406
Main Authors: Shu, Xuemei, Wu, Qiuling, Guo, Tao, Yin, Hua, Liu, Jingdi
Format: Article
Language:English
Subjects:
acute promyelocytic leukemia (APL)
chemotherapy
diagnosis
myeloid sarcoma (MS)
Oncology
spine
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Summary:Myeloid sarcoma is a rare extramedullary tumor of immature myeloid cells. Certain known acute myeloid leukemia cytogenetic abnormalities, in particular t(8,21), has been associated with a higher incidence. Myeloid sarcoma, which rarely happens in acute promyelocytic leukemias, is more common in recurrent patients after the advent of all-trans retinoic acid (ATRA) and are rare in untreated acute promyelocytic leukemia. We described a case of, to our knowledge, myeloid sarcoma of the spine confirmed as acute promyelocytic leukemia. Myeloid sarcoma is diagnosed by spinal tumor biopsy, and microscopic examination of a bone marrow smear and cytogenetic analysis led to a confirmed diagnosis of acute promyelocytic leukemia.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2022.851406