Potential Regulatory Roles of GRK2 in Endothelial Cell Activity and Pathological Angiogenesis

G protein-coupled receptor (GPCR) kinase 2 (GRK2) is an integrative node in many signaling network cascades. Emerging evidence indicates that GRK2 can interact with a large number of GPCRs and non-GPCR substrates in both kinase-dependent and -independent modes. Some of these pathways are associated...

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Bibliographic Details
Published in:Frontiers in immunology 2021-07, Vol.12, p.698424-698424
Main Authors: Kuai, Jiajie, Han, Chenchen, Wei, Wei
Format: Article
Language:English
Subjects:
activity
angiogenesis
Animals
endothelial cells
Endothelial Cells - metabolism
G-Protein-Coupled Receptor Kinase 2 - metabolism
GPCRs
GRK2
Humans
Immunology
Neovascularization, Pathologic - metabolism
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Summary:G protein-coupled receptor (GPCR) kinase 2 (GRK2) is an integrative node in many signaling network cascades. Emerging evidence indicates that GRK2 can interact with a large number of GPCRs and non-GPCR substrates in both kinase-dependent and -independent modes. Some of these pathways are associated with endothelial cell (EC) activity. The active state of ECs is a pivotal factor in angiogenesis. The occurrence and development of some inflammation-related diseases are accompanied by pathological angiogenesis, but there remains a lack of effective targeted treatments. Alterations in the expression and/or localization of GRK2 have been identified in several types of diseases and have been demonstrated to regulate the angiogenesis process in these diseases. GRK2 as a target may be a promising candidate for anti-angiogenesis therapy.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.698424