The Role of Exercise in Maintaining Mitochondrial Proteostasis in Parkinson's Disease

Parkinson's disease (PD) is the second most common rapidly progressive neurodegenerative disease and has serious health and socio-economic consequences. Mitochondrial dysfunction is closely related to the onset and progression of PD, and the use of mitochondria as a target for PD therapy has be...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-04, Vol.24 (9), p.7994
Main Authors: Li, Jingwen, Xu, Yanli, Liu, Tingting, Xu, Yuxiang, Zhao, Xiantao, Wei, Jianshe
Format: Article
Language:English
Subjects:
Brain research
Dopamine
Exercise
Heat shock proteins
Homeostasis
Humans
Kinases
Mitochondria
Mitochondria - metabolism
Mitochondrial DNA
mitochondrial proteostasis
Neurodegeneration
neurodegenerative disease
Neurodegenerative Diseases - metabolism
Neurons
Oxidative phosphorylation
Parkinson Disease - metabolism
Parkinson's disease
Pathogenesis
Phosphorylation
Physical exercise
Physical fitness
Protein folding
Proteostasis
Review
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Summary:Parkinson's disease (PD) is the second most common rapidly progressive neurodegenerative disease and has serious health and socio-economic consequences. Mitochondrial dysfunction is closely related to the onset and progression of PD, and the use of mitochondria as a target for PD therapy has been gaining traction in terms of both recognition and application. The disruption of mitochondrial proteostasis in the brain tissue of PD patients leads to mitochondrial dysfunction, which manifests as mitochondrial unfolded protein response, mitophagy, and mitochondrial oxidative phosphorylation. Physical exercise is important for the maintenance of human health, and has the great advantage of being a non-pharmacological therapy that is non-toxic, low-cost, and universally applicable. In this review, we investigate the relationships between exercise, mitochondrial proteostasis, and PD and explore the role and mechanisms of mitochondrial proteostasis in delaying PD through exercise.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24097994