Trimester-specific thyroid hormone changes in normal pregnant Egyptian women

Introduction The range of normal thyroid functions during pregnancy differs between ethnic groups. Establishment of trimester- and assay-specific reference intervals for every population is recommended. Aim Assessement of the changes in thyroid function tests across the different trimesters in norma...

Full description

Saved in:
Bibliographic Details
Published in:The Egyptian journal of internal medicine 2019-10, Vol.31 (4), p.412-415
Main Authors: Mousa, Shrook, El-Sawy, Shereen S., Abdelraouf, Maged, Farouk, Dina, Rashed, Laila, Saif, Aasem
Format: Article
Language:English
Subjects:
Internal Medicine
Medicine & Public Health
pregnancy
Review Article
thyroid functions
Thyroid gland
thyroid peroxidase antibodies
thyroid-stimulating hormone
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction The range of normal thyroid functions during pregnancy differs between ethnic groups. Establishment of trimester- and assay-specific reference intervals for every population is recommended. Aim Assessement of the changes in thyroid function tests across the different trimesters in normal pregnant Egyptian females. Subjects and methods The study included 150 normal pregnant Egyptian females, recruited from Cairo university hospital antenatal care clinic, with 100 age-matched non-pregnant females, as a control group. Serum thyroid stimulating hormone (TSH) and free thyroxine (FT4) were measured in the three trimesters of pregnancy for every patient. Thyroid peroxidase antibodies (TPO Abs) were also assessed. Our study showed that TSH reference ranges, using the 2.5th and the 97th percentiles, were 0.6–4.3, 0.9–3.7 and 1.0–4.2 mIU/ml for the first, second and third trimesters respectively. The median TSH concentration (50th percentile) was lower in the first trimester (2.1 mIU/ml) in comparison with the second and third trimesters of (2.6 and 2.9 mIU/ml respectively). FT4 reference ranges, using 2.5th to 97th percentile, were 0.9–2 and 0.7–1.4 and 0.6–1.2 ng/dl for the first, second and third trimesters respectively. The median FT4 concentration was higher in the first trimester (1.5 ng/dl) in comparison with the second and third trimesters of (1.1 and 1.0 ng/dl respectively). The percentage of positive TPO Ab was higher in pregnant women than that of age matched non-pregnant ladies (15.3 vs 2%, P
ISSN:1110-7782
2090-9098
DOI:10.4103/ejim.ejim_142_19