Comparative efficacy of intratympanic gentamicin and intratympanic corticosteroid in the treatment of Meniere's disease: a systematic review and meta-analysis

We aimed to evaluate the efficacy of gentamicin compared to corticosteroids for the treatment of Meniere's disease. An extensive search was conducted in PubMed, Embase, and Web of Science until May 2024. For continuous outcomes, pooled effect estimates were determined by calculating the weighte...

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Bibliographic Details
Published in:Frontiers in neurology 2024-09, Vol.15, p.1471010
Main Authors: Wu, Xuanmei, Shui, Jiacheng, Liu, Chengyuan, Wu, Xinyue, Yu, Ying, Wang, Hanyu, Yan, Cong
Format: Article
Language:English
Subjects:
efficacy
intratympanic corticosteroid
intratympanic gentamicin
Meniere’s disease
meta-analysis
Neurology
systematic review
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Summary:We aimed to evaluate the efficacy of gentamicin compared to corticosteroids for the treatment of Meniere's disease. An extensive search was conducted in PubMed, Embase, and Web of Science until May 2024. For continuous outcomes, pooled effect estimates were determined by calculating the weighted mean difference (WMD), while for binary outcomes, the risk ratio (RR) was used, each accompanied by their respective 95% confidence intervals (CIs). Heterogeneity among the studies was assessed using Cochran's and statistics. A total of 12 studies were selected, involving 694 patients. Our analysis found that the gentamicin group demonstrates superior vertigo control rates compared to the corticosteroid group (RR: 1.36, 95% CI: 1.13 to 1.65,  
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2024.1471010