Cytotoxicity and Anti-Plasmodium berghei Activity of Emodin Loaded Nanoemulsion

Background: Malaria parasites cause a tremendous burden of disease in both the tropics and subtropics areas. Growing of drugs resistance in parasites is one of the most threats to malaria control. The aim of study was to investigate the anti-malarial activity of nano-emodin isolated from Rhamnus cat...

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Published in:Iranian journal of parasitology 2022-07, Vol.17 (3), p.339
Main Authors: Bayat, Fatemeh, Motevalli Haghi, Afsaneh, Nateghpour, Mehdi, Rahimi-Esboei, Bahman, Foroushani, Abbas Rahimi, Amani, Amir, Farivar, Leila, Talaee, Zahra Sayyad, Faryabi, Aref
Format: Article
Language:English
Subjects:
In-vivo test
Malaria
Nano emodin
Parasites
Plasmodium berghei
Rhamnus cathartica
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Summary:Background: Malaria parasites cause a tremendous burden of disease in both the tropics and subtropics areas. Growing of drugs resistance in parasites is one of the most threats to malaria control. The aim of study was to investigate the anti-malarial activity of nano-emodin isolated from Rhamnus cathartica on Plasmodium berghei in mice to evaluate parasites inhibition rate using in-vivo test. Methods: The study was conducted in the School of Public Health, Tehran University of Medical Sciences, during 2020. Nano- emodin particles were prepared from Rhamnus cathartica, and confirmed by Zeta Potential Analyzer, DLS and electron microscopy techniques. Mice were infected with P. berghei and treated by emodin nanoparticles. Parasitemia was evaluated in each group in comparison with control group. Toxicity test was done using twice the highest concentration of emodin extract on a separate group of mice and ED50 was calculated. Results: Emodin extract was significantly effective in all concentrations on D4 (P
ISSN:1735-7020
2008-238X
DOI:10.18502/ijpa.v17i3.10624