Synergy of antioxidant and M2 polarization in polyphenol‐modified konjac glucomannan dressing for remodeling wound healing microenvironment

Effective skin wound healing and tissue regeneration remain a challenge. Excessive/chronic inflammation inhibits wound healing, leading to scar formation. Herein, we report a wound dressing composed of KGM‐GA based on the natural substances konjac glucomannan (KGM) and gallic acid (GA) that accelera...

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Bibliographic Details
Published in:Bioengineering & translational medicine 2023-03, Vol.8 (2), p.e10398-n/a
Main Authors: Li, Huiyang, Liang, Xiaoyu, Chen, Youlu, Liu, Kaijing, Fu, Xue, Zhang, Chuangnian, Wang, Xiaoli, Yang, Jing
Format: Article
Language:English
Subjects:
Angiogenesis
Antioxidants
bioactive dressing
Biocompatibility
Biological activity
Biomedical materials
Cytokines
Cytotoxicity
Gallic acid
Genotype & phenotype
In vivo methods and tests
Inflammation
M2 macrophage
Pathogens
Polarization
Regeneration (physiology)
ROS scavenging
Scanning electron microscopy
Skin
Stem cells
Tissue engineering
Wound healing
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Summary:Effective skin wound healing and tissue regeneration remain a challenge. Excessive/chronic inflammation inhibits wound healing, leading to scar formation. Herein, we report a wound dressing composed of KGM‐GA based on the natural substances konjac glucomannan (KGM) and gallic acid (GA) that accelerates wound healing without any additional drugs. An in vitro study showed that KGM‐GA could not only stimulate macrophage polarization to the anti‐inflammatory M2 phenotype but also decrease reactive oxygen species (ROS) levels, indicating excellent anti‐inflammatory properties. Moreover, in vivo studies of skin wounds demonstrated that the KGM‐GA dressing significantly improved wound healing by accelerating wound closure, collagen deposition, and angiogenesis. In addition, it was observed that KGM‐GA regulated M2 polarization, reducing the production of intracellular ROS in the wound microenvironment, which was consistent with the in vitro experiments. Therefore, this study designed a multifunctional biomaterial with biological activity, providing a novel dressing for wound healing.
ISSN:2380-6761
2380-6761
DOI:10.1002/btm2.10398