Trans-Axonal Signaling in Neural Circuit Wiring

The development of neural circuits is a complex process that relies on the proper navigation of axons through their environment to their appropriate targets. While axon-environment and axon-target interactions have long been known as essential for circuit formation, communication between axons thems...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-07, Vol.21 (14), p.5170
Main Authors: Spead, Olivia, Poulain, Fabienne E
Format: Article
Language:English
Subjects:
Ablation
adhesion
Animals
Antibodies
Axon guidance
Axonogenesis
Axons
Axons - metabolism
Axons - physiology
axon–axon communication
Cell adhesion & migration
Degeneration
fasciculation
Fasciculation - metabolism
growth cone
Growth Cones - physiology
guidance
Immunoglobulins
Insects
Molecular modelling
Neural Conduction - physiology
Neural networks
Neurons
repulsion
Review
Signal Transduction - physiology
Spinal cord
Vertebrates
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Summary:The development of neural circuits is a complex process that relies on the proper navigation of axons through their environment to their appropriate targets. While axon-environment and axon-target interactions have long been known as essential for circuit formation, communication between axons themselves has only more recently emerged as another crucial mechanism. Trans-axonal signaling governs many axonal behaviors, including fasciculation for proper guidance to targets, defasciculation for pathfinding at important choice points, repulsion along and within tracts for pre-target sorting and target selection, repulsion at the target for precise synaptic connectivity, and potentially selective degeneration for circuit refinement. This review outlines the recent advances in identifying the molecular mechanisms of trans-axonal signaling and discusses the role of axon-axon interactions during the different steps of neural circuit formation.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21145170