Aqueous fruit pulp extract of Adansonia digitata (L) protects against lead-acetate-induced hepato-renal damage in rat model

Background Adansonia digitata (L) fruit has a multi-purpose function one among many, is the antioxidant activities of the fruit by preventing oxidative stress. The effect of Adansonia digitata (L) fruit on lead-induced liver and kidney damage is not clear. Hence, the study was aimed to assessed the...

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Published in:Beni-Suef University journal of basic and applied sciences 2021-09, Vol.10 (1), p.59-7, Article 59
Main Authors: Makena, Wusa, Otong, Eduitem Sunday, Dibal, Nathan Isaac, Ishaku, Barka, Bazabang, Sebastine Anthony
Format: Article
Language:English
Subjects:
Adansonia
Adansonia digitata
Biochemical analysis
Creatinine
Damage
Degeneration
Dimercaptosuccinic acid
Enzymes
Fatty liver
Food contamination & poisoning
Fruits
Glomerulus
Histology
Kidney
Kidneys
Lead acetate
Lead acetates
Liver
Medicine
Medicine & Public Health
Organs
Oxidative stress
Parameters
Polyphenols
Steatosis
Succimer
Therapeutic applications
Toxicity
Ureas
Uric acid
Variance analysis
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Summary:Background Adansonia digitata (L) fruit has a multi-purpose function one among many, is the antioxidant activities of the fruit by preventing oxidative stress. The effect of Adansonia digitata (L) fruit on lead-induced liver and kidney damage is not clear. Hence, the study was aimed to assessed the protective role of Adansonia digitata (L) fruits against lead acetate induced changes in the liver and kidney function test parameters and the histology of both organ in experimental rats. The rats were divided into five groups with five rats each. All the rats were administered with respective assigned treatment once daily for 6 weeks. Rats in groups I were administered with just distil water (2 ml/kg). Rats in groups II were administered with lead acetate (30 mg/kg) while rats in groups III–V were administered Adansonia digitatata (L) fruit extract (250 mg/kg and 500 mg/kg) and Succimer (5 mg/kg) respectively, then additionally challenged with lead acetate (30 mg/kg) immediately after. At the end of the administration, the blood serum from the experimental rats were used for biochemical analysis. Then, the the organs such as the liver and kidney collected for histological study. Results Rats administered with Lead acetate showed an increase in AST, ALP and ALT as well as increase in urea and creatinine level ( p  
ISSN:2314-8543
2314-8535
2314-8543
DOI:10.1186/s43088-021-00151-6