Aqueous fruit pulp extract of Adansonia digitata (L) protects against lead-acetate-induced hepato-renal damage in rat model

Background Adansonia digitata (L) fruit has a multi-purpose function one among many, is the antioxidant activities of the fruit by preventing oxidative stress. The effect of Adansonia digitata (L) fruit on lead-induced liver and kidney damage is not clear. Hence, the study was aimed to assessed the...

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Published in:Beni-Suef University journal of basic and applied sciences 2021-09, Vol.10 (1), p.59-7, Article 59
Main Authors: Makena, Wusa, Otong, Eduitem Sunday, Dibal, Nathan Isaac, Ishaku, Barka, Bazabang, Sebastine Anthony
Format: Article
Language:English
Subjects:
Adansonia
Adansonia digitata
Biochemical analysis
Creatinine
Damage
Degeneration
Dimercaptosuccinic acid
Enzymes
Fatty liver
Food contamination & poisoning
Fruits
Glomerulus
Histology
Kidney
Kidneys
Lead acetate
Lead acetates
Liver
Medicine
Medicine & Public Health
Organs
Oxidative stress
Parameters
Polyphenols
Steatosis
Succimer
Therapeutic applications
Toxicity
Ureas
Uric acid
Variance analysis
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description Background Adansonia digitata (L) fruit has a multi-purpose function one among many, is the antioxidant activities of the fruit by preventing oxidative stress. The effect of Adansonia digitata (L) fruit on lead-induced liver and kidney damage is not clear. Hence, the study was aimed to assessed the protective role of Adansonia digitata (L) fruits against lead acetate induced changes in the liver and kidney function test parameters and the histology of both organ in experimental rats. The rats were divided into five groups with five rats each. All the rats were administered with respective assigned treatment once daily for 6 weeks. Rats in groups I were administered with just distil water (2 ml/kg). Rats in groups II were administered with lead acetate (30 mg/kg) while rats in groups III–V were administered Adansonia digitatata (L) fruit extract (250 mg/kg and 500 mg/kg) and Succimer (5 mg/kg) respectively, then additionally challenged with lead acetate (30 mg/kg) immediately after. At the end of the administration, the blood serum from the experimental rats were used for biochemical analysis. Then, the the organs such as the liver and kidney collected for histological study. Results Rats administered with Lead acetate showed an increase in AST, ALP and ALT as well as increase in urea and creatinine level ( p  
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The effect of Adansonia digitata (L) fruit on lead-induced liver and kidney damage is not clear. Hence, the study was aimed to assessed the protective role of Adansonia digitata (L) fruits against lead acetate induced changes in the liver and kidney function test parameters and the histology of both organ in experimental rats. The rats were divided into five groups with five rats each. All the rats were administered with respective assigned treatment once daily for 6 weeks. Rats in groups I were administered with just distil water (2 ml/kg). Rats in groups II were administered with lead acetate (30 mg/kg) while rats in groups III–V were administered Adansonia digitatata (L) fruit extract (250 mg/kg and 500 mg/kg) and Succimer (5 mg/kg) respectively, then additionally challenged with lead acetate (30 mg/kg) immediately after. At the end of the administration, the blood serum from the experimental rats were used for biochemical analysis. Then, the the organs such as the liver and kidney collected for histological study. Results Rats administered with Lead acetate showed an increase in AST, ALP and ALT as well as increase in urea and creatinine level ( p  &lt; 0.001), when compared with the control group (group I), where as Adansonia digitatata (L) fruit prevented the effect (upsurge of serum, Urea, Creatinine, AST, ALP and ALT) of lead acetate. Rats administer with only Lead acetate revealed marked liver steatosis and the degeneration of the kidney glomerulus. The Adansonia digitatata (L) fruit extract and Succimer prevented the histological liver steatosis, as well as the degeneration of the glomerulus of the kidney cytoarchitecture. Conclusion The findings in this study suggest that Adansonia digitata fruits extract has a protective potentials against lead acetate induced liver and kidney toxicity by preventing the upsurge of liver function enzymes and kidney function parameters. Hence, Adansonia digitata fruits can serve as a natural plant agent that can prevent hepato-renal toxicity. Therefore, Adansonia digitata holds future prospects in preclinical framework to ameliorate organs toxicity for oral therapeutic applications.</description><identifier>ISSN: 2314-8543</identifier><identifier>ISSN: 2314-8535</identifier><identifier>EISSN: 2314-8543</identifier><identifier>DOI: 10.1186/s43088-021-00151-6</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adansonia ; Adansonia digitata ; Biochemical analysis ; Creatinine ; Damage ; Degeneration ; Dimercaptosuccinic acid ; Enzymes ; Fatty liver ; Food contamination &amp; poisoning ; Fruits ; Glomerulus ; Histology ; Kidney ; Kidneys ; Lead acetate ; Lead acetates ; Liver ; Medicine ; Medicine &amp; Public Health ; Organs ; Oxidative stress ; Parameters ; Polyphenols ; Steatosis ; Succimer ; Therapeutic applications ; Toxicity ; Ureas ; Uric acid ; Variance analysis</subject><ispartof>Beni-Suef University journal of basic and applied sciences, 2021-09, Vol.10 (1), p.59-7, Article 59</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. 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The effect of Adansonia digitata (L) fruit on lead-induced liver and kidney damage is not clear. Hence, the study was aimed to assessed the protective role of Adansonia digitata (L) fruits against lead acetate induced changes in the liver and kidney function test parameters and the histology of both organ in experimental rats. The rats were divided into five groups with five rats each. All the rats were administered with respective assigned treatment once daily for 6 weeks. Rats in groups I were administered with just distil water (2 ml/kg). Rats in groups II were administered with lead acetate (30 mg/kg) while rats in groups III–V were administered Adansonia digitatata (L) fruit extract (250 mg/kg and 500 mg/kg) and Succimer (5 mg/kg) respectively, then additionally challenged with lead acetate (30 mg/kg) immediately after. At the end of the administration, the blood serum from the experimental rats were used for biochemical analysis. Then, the the organs such as the liver and kidney collected for histological study. Results Rats administered with Lead acetate showed an increase in AST, ALP and ALT as well as increase in urea and creatinine level ( p  &lt; 0.001), when compared with the control group (group I), where as Adansonia digitatata (L) fruit prevented the effect (upsurge of serum, Urea, Creatinine, AST, ALP and ALT) of lead acetate. Rats administer with only Lead acetate revealed marked liver steatosis and the degeneration of the kidney glomerulus. The Adansonia digitatata (L) fruit extract and Succimer prevented the histological liver steatosis, as well as the degeneration of the glomerulus of the kidney cytoarchitecture. Conclusion The findings in this study suggest that Adansonia digitata fruits extract has a protective potentials against lead acetate induced liver and kidney toxicity by preventing the upsurge of liver function enzymes and kidney function parameters. 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The effect of Adansonia digitata (L) fruit on lead-induced liver and kidney damage is not clear. Hence, the study was aimed to assessed the protective role of Adansonia digitata (L) fruits against lead acetate induced changes in the liver and kidney function test parameters and the histology of both organ in experimental rats. The rats were divided into five groups with five rats each. All the rats were administered with respective assigned treatment once daily for 6 weeks. Rats in groups I were administered with just distil water (2 ml/kg). Rats in groups II were administered with lead acetate (30 mg/kg) while rats in groups III–V were administered Adansonia digitatata (L) fruit extract (250 mg/kg and 500 mg/kg) and Succimer (5 mg/kg) respectively, then additionally challenged with lead acetate (30 mg/kg) immediately after. At the end of the administration, the blood serum from the experimental rats were used for biochemical analysis. Then, the the organs such as the liver and kidney collected for histological study. Results Rats administered with Lead acetate showed an increase in AST, ALP and ALT as well as increase in urea and creatinine level ( p  &lt; 0.001), when compared with the control group (group I), where as Adansonia digitatata (L) fruit prevented the effect (upsurge of serum, Urea, Creatinine, AST, ALP and ALT) of lead acetate. Rats administer with only Lead acetate revealed marked liver steatosis and the degeneration of the kidney glomerulus. The Adansonia digitatata (L) fruit extract and Succimer prevented the histological liver steatosis, as well as the degeneration of the glomerulus of the kidney cytoarchitecture. Conclusion The findings in this study suggest that Adansonia digitata fruits extract has a protective potentials against lead acetate induced liver and kidney toxicity by preventing the upsurge of liver function enzymes and kidney function parameters. Hence, Adansonia digitata fruits can serve as a natural plant agent that can prevent hepato-renal toxicity. Therefore, Adansonia digitata holds future prospects in preclinical framework to ameliorate organs toxicity for oral therapeutic applications.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43088-021-00151-6</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9743-7844</orcidid><oa>free_for_read</oa></addata></record>
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subjects Adansonia
Adansonia digitata
Biochemical analysis
Creatinine
Damage
Degeneration
Dimercaptosuccinic acid
Enzymes
Fatty liver
Food contamination & poisoning
Fruits
Glomerulus
Histology
Kidney
Kidneys
Lead acetate
Lead acetates
Liver
Medicine
Medicine & Public Health
Organs
Oxidative stress
Parameters
Polyphenols
Steatosis
Succimer
Therapeutic applications
Toxicity
Ureas
Uric acid
Variance analysis
title Aqueous fruit pulp extract of Adansonia digitata (L) protects against lead-acetate-induced hepato-renal damage in rat model
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