Flavonoids from Brazilian Cerrado: Biosynthesis, Chemical and Biological Profile

Flavonoids are highly bioactive compounds with very low toxicity, which makes them attractive starting points in drug discovery. This study aims to provide information on plant species containing flavonoids, which are found in the Brazilian Cerrado. First, we present the characterization and plant d...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2019-08, Vol.24 (16), p.2891
Main Authors: Peixoto, Josana de Castro, Neves, Bruno Junior, Vasconcelos, Flávia Gonçalves, Napolitano, Hamilton Barbosa, Barbalho, Maria Gonçalves da Silva, Silva, Sandro Dutra E, Rosseto, Lucimar Pinheiro
Format: Article
Language:English
Subjects:
Bioactive compounds
Biocompatibility
Biodiversity
Biosynthesis
Brazil
Brazilian Cerrado
Cultural heritage
Ecosystems
Endangered & extinct species
Enzymes
Flavonoids
Flavonoids - biosynthesis
Flowers & plants
Metabolites
Pharmaceutical industry
Plant diversity
Plant species
Plants - metabolism
Review
Species Specificity
Toxicity
Vegetation
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Summary:Flavonoids are highly bioactive compounds with very low toxicity, which makes them attractive starting points in drug discovery. This study aims to provide information on plant species containing flavonoids, which are found in the Brazilian Cerrado. First, we present the characterization and plant diversity with emphasis on the families of flavonoid-producing plants, and then we describe the phenylpropanoid pathway which represents the flavonoids' main route biosynthesis-generally conserved in all species. Chemical structures and biological activities of flavonoids isolated from the Cerrado's plant species are also described based on examples from the relevant literature studies. Finally, research on the biodiversity of the Cerrado biome should be encouraged, due to the discovery of new sources of flavonoids which can provide several benefits to human health and the possibility of developing new drugs by the pharmaceutical industry.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24162891