A registration trend in eyelid skin cancers and associated risk factors in Iran, 2005–2016

• Published in: BMC cancer 2023-09, Vol.23 (1), p.1-924, Article 924
• Main Authors: Safi, Sare, Ahmadzade, Mohadese, Karimi, Saeed, Akbari, Mohammad Esmaeil, Rouientan, Hamidreza, Abolhosseini, Mohammad, Rezaei Kanavi, Mozhgan, Khorrami, Zahra
• Format: Article
• Language: English
• Subjects: Age factors in disease; Age groups; Age-standardized incidence rates; Analysis; Basal cell carcinoma; Blood pressure; Body weight; Cancer; Carcinoma; Care and treatment; Demographic aspects; Diagnosis; Eye diseases; Eyelid; Eyelid diseases; Eyelid skin cancers; Gender; Health aspects; Industrialized nations; Iran; Lifestyles; Malignancy; Melanoma; Morphology; Multivariate analysis; Obesity; Oncology, Experimental; Overweight; Population; Provinces; Regression analysis; Risk factors; Skin; Skin cancer; Smoking; Trends
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-023-11414-z

Background Eyelid skin cancers are the most prevalent ophthalmic malignancies. This study aimed to evaluate the association of the Human Development Index (HDI) and lifestyle risk factors with eyelid skin cancers in Iran. Methods This ecological study analyzed the data collected from the Iranian National Population-based Cancer Registry (2005-2016). The data on provincial-level eyelid skin cancer risk factors were obtained from national sources. The association between provincial HDI and lifestyle risk factors with the prevalence of eyelid skin cancers was assessed. Results The mean 12-year age-standardized incidence rate (ASIR) of eyelid skin cancers was 16.22 per 100,000 (9,104 cases). The overall ASIR showed an upward trend with an estimated annual average increase of 0.006 per year. There were positive correlations between the prevalence of overall eyelid skin cancers and provincial HDI, smoking, and obesity (r = 0.32, 0.42, and 0.37, respectively). In multivariate analysis, obesity/overweight remained a positive predictor for high prevalence of total eyelid skin cancers (OR = 1.97, 95%CI = 1.08-3.58, P = 0.026), carcinoma (2.10, 1.15-3.83, P = 0.015), and basal cell carcinoma (1.48, 0.99-2.20, P = 0.054). Conclusions An increasing trend in ASIR of eyelid skin cancers was observed in more than a decade in Iran which was positively associated with provincial HDI and prevalence of obesity. The findings of the study highlight the importance of promotional programs for preventing obesity/overweight and appropriate allocation of screening facilities based on the HDI level. Keywords: Eyelid skin cancers, Age-standardized incidence rates, Risk factors, Iran