Piroxicam voltammetric determination by ultra low cost pencil graphite electrode

Piroxicam (PRX) was determined in pharmaceutical capsules with differential pulse voltammetry (DPV) in a three electrode system consisting of a pencil graphite electrode (PGE) as working electrode, a Pt wire and a reference electrode of Ag/AgCl/KCl 3 M. An irreversible oxidation peak was observed in...

Full description

Saved in:
Bibliographic Details
Published in:Brazilian Journal of Pharmaceutical Sciences 2020-01, Vol.56
Main Authors: Macêdo, Isaac Yves Lopes de, Alecrim, Morgana Fernandes, Oliveira Neto, Jerônimo Raimundo, Torres, Ieda Maria Sapateiro, Thomaz, Douglas Vieira, Gil, Eric de Souza
Format: Article
Language:English
Subjects:
Caustic soda
Electroanalysis
Electrodes
Experiments
Graphite
Homogenization
Oxidation
Pencil graphite electrode
Pharmaceuticals
PHARMACOLOGY & PHARMACY
Piroxicam
Quality control
Voltammetry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Piroxicam (PRX) was determined in pharmaceutical capsules with differential pulse voltammetry (DPV) in a three electrode system consisting of a pencil graphite electrode (PGE) as working electrode, a Pt wire and a reference electrode of Ag/AgCl/KCl 3 M. An irreversible oxidation peak was observed in Epa c.a. 0.6 V, which correlates to the oxidation of PRX. The coefficient of linear correlation obtained was 0.9946, with limit of detection of 2.1 µM and limit of quantification of 4.7 µM. PGE assays showed good analytical performance compared to high performance liquid chromatography and spectrophotometry, showing the potential to be further developed and employed in quick and simple analyses.
ISSN:2175-9790
1984-8250
2175-9790
DOI:10.1590/s2175-97902019000317344