Molecular Perspectives on Prostate Cancer: The Role of microRNAs in Androgen Receptor Regulation

Prostate cancer (PCa) is the most prevalent cancer among men globally. In addition to environmental risk factors, genetic factors play a crucial role in its development and progression, highlighting the regulation of key genes as an essential aspect. The androgen receptor gene (AR) plays a pivotal r...

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Bibliographic Details
Published in:Receptors 2024-11, Vol.3 (4), p.494-512
Main Authors: Garibaldi-Ríos, Asbiel Felipe, Rivera-Cameras, Alicia, Figuera, Luis E., Zúñiga-González, Guillermo Moisés, Gómez-Meda, Belinda Claudia, García-Ortíz, José Elías, Gallegos-Arreola, Martha Patricia
Format: Article
Language:English
Subjects:
androgen receptor
gene expression regulation
microRNAs
prostatic neoplasms
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Summary:Prostate cancer (PCa) is the most prevalent cancer among men globally. In addition to environmental risk factors, genetic factors play a crucial role in its development and progression, highlighting the regulation of key genes as an essential aspect. The androgen receptor gene (AR) plays a pivotal role in this disease, so its post-transcriptional regulation must be meticulously coordinated. In this review, we explore the role of microRNAs (miRNAs) in the regulation of AR in PCa, a field not yet fully investigated. We note that the AR, due to its extensive 3′UTR region, is targeted by numerous miRNAs, and that this regulation can occur at different levels: directly, indirectly, and through mutual regulation, thus amplifying the influence of these molecules on AR regulation.
ISSN:2813-2564
2813-2564
DOI:10.3390/receptors3040025