Xerogels Morphology Details by Multifractal Analysis and Scanning Electron Microscopy Images Evaluations of 5-Fluorouracil Release from Chitosan-Based Matrix

Four medicament delivery formulations based on 5-fluorouracil in a chitosan substantial matrix were realized in situ via 3,7-dimethyl-2,6-octadienal element hydrogelation. Representative samples of the final realized compounds were investigated from an analytic, constitutional, and morphological vie...

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Bibliographic Details
Published in:Gels 2022-12, Vol.8 (12), p.820
Main Authors: Paun, Maria-Alexandra, Nichita, Mihai-Virgil, Paun, Vladimir-Alexandru, Paun, Viorel-Puiu
Format: Article
Language:English
Subjects:
5-fluorouracil
Bioavailability
Chemical elements
Chitosan
chitosan hydrogels
Cosmetics
Electron microscopy
Fluorouracil
Formulations
Fourier transforms
Fractal analysis
Fractal geometry
Fractals
Hydrogels
Infrared analysis
Mathematical analysis
Morphology
multifractal dynamics
Nanoparticles
Polymers
Scanning electron microscopy
SEM images
Xerogels
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Summary:Four medicament delivery formulations based on 5-fluorouracil in a chitosan substantial matrix were realized in situ via 3,7-dimethyl-2,6-octadienal element hydrogelation. Representative samples of the final realized compounds were investigated from an analytic, constitutional, and morphological viewpoint via Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The SEM images of the formulations were investigated in concordance with fractal analysis, and the fractal dimensions and lacunarity were computed. The developed mathematical multifractal model is necessarily confirmed by the experimental measurements corresponding to the 5-fluorouracil release outside the chitosan-formed matrix.
ISSN:2310-2861
2310-2861
DOI:10.3390/gels8120820