Automated Opportunistic Osteoporosis Screening Using Low-Dose Chest CT among Individuals Undergoing Lung Cancer Screening in a Korean Population

Opportunistic osteoporosis screening using deep learning (DL) analysis of low-dose chest CT (LDCT) scans is a potentially promising approach for the early diagnosis of this condition. We explored bone mineral density (BMD) profiles across all adult ages and prevalence of osteoporosis using LDCT with...

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Bibliographic Details
Published in:Diagnostics (Basel) 2024-08, Vol.14 (16), p.1789
Main Authors: Kang, Woo Young, Yang, Zepa, Park, Heejun, Lee, Jemyoung, Hong, Suk-Joo, Shim, Euddeum, Woo, Ok Hee
Format: Article
Language:English
Subjects:
Automation
Bone density
bone mineral density
Calcification
Cancer
computed tomography
CT imaging
Datasets
Deep learning
Diagnosis
Diagnostic imaging
Fractures
Hospitals
Lung cancer
Mechanization
Medical imaging
Medical imaging equipment
Medical screening
opportunistic screening
Osteoporosis
Patients
prevalence
Radiation
South Korea
Technology application
Tomography
Vertebrae
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Summary:Opportunistic osteoporosis screening using deep learning (DL) analysis of low-dose chest CT (LDCT) scans is a potentially promising approach for the early diagnosis of this condition. We explored bone mineral density (BMD) profiles across all adult ages and prevalence of osteoporosis using LDCT with DL in a Korean population. This retrospective study included 1915 participants from two hospitals who underwent LDCT during general health checkups between 2018 and 2021. Trabecular volumetric BMD of L1-2 was automatically calculated using DL and categorized according to the American College of Radiology quantitative computed tomography diagnostic criteria. BMD decreased with age in both men and women. Women had a higher peak BMD in their twenties, but lower BMD than men after 50. Among adults aged 50 and older, the prevalence of osteoporosis and osteopenia was 26.3% and 42.0%, respectively. Osteoporosis prevalence was 18.0% in men and 34.9% in women, increasing with age. Compared to previous data obtained using dual-energy X-ray absorptiometry, the prevalence of osteoporosis, particularly in men, was more than double. The automated opportunistic BMD measurements using LDCT can effectively predict osteoporosis for opportunistic screening and identify high-risk patients. Patients undergoing lung cancer screening may especially profit from this procedure requiring no additional imaging or radiation exposure.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics14161789