Radiation-Induced Rescue Effect: Insights from Microbeam Experiments

The present paper reviews a non-targeted effect in radiobiology known as the Radiation-Induced Rescue Effect (RIRE) and insights gained from previous microbeam experiments on RIRE. RIRE describes the mitigation of radiobiological effects in targeted irradiated cells after they receive feedback signa...

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Bibliographic Details
Published in:Biology (Basel, Switzerland) Switzerland), 2022-10, Vol.11 (11), p.1548
Main Author: Yu, Kwan Ngok
Format: Article
Language:English
Subjects:
Cancer
Communication
Cooperation
Experiments
Feedback
Ionizing radiation
Metabolism
microbeam
non-targeted effect
radiation biology
Radiation therapy
Review
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Summary:The present paper reviews a non-targeted effect in radiobiology known as the Radiation-Induced Rescue Effect (RIRE) and insights gained from previous microbeam experiments on RIRE. RIRE describes the mitigation of radiobiological effects in targeted irradiated cells after they receive feedback signals from co-cultured non-irradiated bystander cells, or from the medium previously conditioning those co-cultured non-irradiated bystander cells. RIRE has established or has the potential of establishing relationships with other non-traditional new developments in the fields of radiobiology, including Radiation-Induced Bystander Effect (RIBE), Radiation-Induced Field Size Effect (RIFSE) and ultra-high dose rate (FLASH) effect, which are explained. The paper first introduces RIRE, summarizes previous findings, and surveys the mechanisms proposed for observations. Unique opportunities offered by microbeam irradiations for RIRE research and some previous microbeam studies on RIRE are then described. Some thoughts on future priorities and directions of research on RIRE exploiting unique features of microbeam radiations are presented in the last section.
ISSN:2079-7737
2079-7737
DOI:10.3390/biology11111548