The Effect of Quercus coccifera L. Extract on the Necrosis of Random-pattern Skin Flaps in Rats

Aim: Ischemia-reperfusion injury is an important cause of flap loss. We investigated effects of Quercus coccifera L. extract known to have anti-oxidant and anti-inflammatory activity on skin flap viability. Methods: Eighteen Wistar rats were used. Random-pattern skin flaps, 9x3 cm in size, were appl...

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Bibliographic Details
Published in:Haseki tıp bülteni 2019-09, Vol.57 (3), p.249-254
Main Authors: Orhan, Erkan, Özkaya Aka, İlsun, Yüzbaşıoğlu, Merve, Yavuz, Burçin, Bilensoy, Erem, Kuruüzüm Uz, Ayşe
Format: Article
Language:English
Subjects:
Antioxidants
Ischemia
Metabolites
Necrosis
Quercus coccifera L
Sağlık Hizmetleri
skin flap
Studies
Surgery
Tıp
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Summary:Aim: Ischemia-reperfusion injury is an important cause of flap loss. We investigated effects of Quercus coccifera L. extract known to have anti-oxidant and anti-inflammatory activity on skin flap viability. Methods: Eighteen Wistar rats were used. Random-pattern skin flaps, 9x3 cm in size, were applied on rats back and then the rats were divided into three groups. Following surgery, 2 cc of nitrofurazone cream and 2 cc of Q. coccifera L. water extract were applied daily in groups 2 and 3, respectively. Group 1 received no treatment after surgery. The percentage of necrosis on the flaps was calculated and histopathological examination of the tissue samples was made on day 7. Results: The mean percentage of necrosis was 44.7%, 42.5% and 21.8% group 1, 2 and 3, respectively. The percentage of necrosis was statistically significantly lower in group 3 than in groups 1 and 2 (p
ISSN:1302-0072
2147-2688
DOI:10.4274/haseki.galenos.2018.4533