Malignancy Grade–Dependent Expression of K+-Channel Subtypes in Human Prostate Cancer

K+ channels are key molecules in the progression of several cancer types and considered to be potential targets for cancer therapy. We examined the gene expressions of voltage-gated (Kv), Ca2+-activated (KCa), and two-pore domain (K2P) K+-channel subtypes in needle-biopsy samples of human prostate c...

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Bibliographic Details
Published in:Journal of Pharmacological Sciences 2009, Vol.109(1), pp.148-151
Main Authors: Ohya, Susumu, Kimura, Kazunori, Niwa, Satomi, Ohno, Akitoshi, Kojima, Yoshiyuki, Sasaki, Shoichi, Kohri, Kenjiro, Imaizumi, Yuji
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Cell Line, Tumor
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
K+ channel
Male
Neoplasm Staging
Potassium Channels - genetics
prostate cancer
Prostate-Specific Antigen - blood
Prostatic Neoplasms - blood
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Protein Isoforms - genetics
Reverse Transcriptase Polymerase Chain Reaction - methods
tumor marker
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Summary:K+ channels are key molecules in the progression of several cancer types and considered to be potential targets for cancer therapy. We examined the gene expressions of voltage-gated (Kv), Ca2+-activated (KCa), and two-pore domain (K2P) K+-channel subtypes in needle-biopsy samples of human prostate cancer (PCa) by real-time PCR and compared them with those in PCa epithelial cell lines. The expression of Kv1.3, KCa1.1, KCa3.1, and K2P1 markedly increased in the PCa group with Gleason score of 5 – 6 (GS5–6) but significantly decreased in the GS8–9 group. This malignancy grade–dependent K+-channel expression pattern may provide a convenient marker to understand PCa progression level.
ISSN:1347-8613
1347-8648
DOI:10.1254/jphs.08208SC