Dietary Mannan Oligosaccharides Modulate Gut Inflammatory Response and Improve Duodenal Villi Height in Post-Weaning Piglets Improving Feed Efficiency

The aim of this study was to evaluate the effects of mannan oligosaccharides (MOS) on gut health and performance in post-weaning piglets. In total, 40 piglets were divided into two experimental groups and fed a basal diet with (TRT) or without (CON) 0.2% mannan oligosaccharides for 35 days. Growth p...

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Published in:Animals (Basel) 2020-08, Vol.10 (8), p.1283
Main Authors: Agazzi, Alessandro, Perricone, Vera, Zorini, Fabio Omodei, Sandrini, Silvia, Mariani, Elena, Jiang, Xian- Ren, Ferrari, Alessandra, Crestani, Maurizio, Nguyen, Thi Xuan, Bontempo, Valentino, Domeneghini, Cinzia, Savoini, Giovanni
Format: Article
Language:English
Subjects:
Antimicrobial agents
Colon
Cytokines
Diet
Efficiency
faecal microbiota
Feed efficiency
Feeds
Gene expression
Genes
gut health
Health aspects
Hogs
Immune system
Inflammation
Inflammatory response
intestinal morphology
Investigations
Mannan
mannan oligosaccharides
Microbiota
Microorganisms
Nutrition research
Oligosaccharides
post-weaning piglets
Prebiotics
Swine
TLR4 protein
Toll-like receptors
Tumor necrosis factor
Tumors
Ventilation
Weaning
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Summary:The aim of this study was to evaluate the effects of mannan oligosaccharides (MOS) on gut health and performance in post-weaning piglets. In total, 40 piglets were divided into two experimental groups and fed a basal diet with (TRT) or without (CON) 0.2% mannan oligosaccharides for 35 days. Growth performance was determined weekly and faecal microbial composition on days 0, 14 and 35. On day 36, histometrical evaluations were performed on duodenal, jejunal, ileal, and colon samples. mRNA gene expression of inflammation-related genes was evaluated in samples of ileal Peyer’s patches (IPP). MOS administration improved feed efficiency in the last two weeks of the trial (p < 0.05), and a decreased clostridia content was found in faeces at day 14 (p = 0.05). TRT piglets showed increased duodenal villi height (p < 0.05), and reduced mRNA levels of Tumour Necrosis Factor α (p < 0.05) and Toll-Like Receptor 4 (p < 0.01) in IPP. Our results suggest beneficial effects of MOS supplementation on gut morphology and the expression of inflammation-related genes in post-weaning piglets, accompanied by increased feed efficiency.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani10081283