The association between acylcarnitine and amino acids profile and metabolic syndrome and its components in Iranian adults: Data from STEPs 2016

Evidence, albeit with conflicting results, has suggested that cardiometabolic risk factors, including obesity, type 2 diabetes (T2D), dyslipidemia, and hypertension, are highly associated with changes in metabolic signature, especially plasma amino acids and acylcarnitines levels. Here, we aimed to...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2023-02, Vol.14, p.1058952-1058952
Main Authors: Taghizadeh, Hananeh, Emamgholipour, Solaleh, Hosseinkhani, Shaghayegh, Arjmand, Babak, Rezaei, Negar, Dilmaghani-Marand, Arezou, Ghasemi, Erfan, Panahi, Nekoo, Dehghanbanadaki, Hojat, Ghodssi-Ghassemabadi, Robabeh, Najjar, Niloufar, Asadi, Mojgan, Khoshniat, Mohsen, Larijani, Bagher, Razi, Farideh
Format: Article
Language:English
Subjects:
acylcarnitine
Adult
amino acid
Carnitine
Chromatography, Liquid
Citrulline
Cross-Sectional Studies
Diabetes Mellitus, Type 2
Endocrinology
Humans
Iran - epidemiology
metabolic syndrome
Metabolic Syndrome - epidemiology
metabolites
metabolomics
Tandem Mass Spectrometry
Trypsin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Evidence, albeit with conflicting results, has suggested that cardiometabolic risk factors, including obesity, type 2 diabetes (T2D), dyslipidemia, and hypertension, are highly associated with changes in metabolic signature, especially plasma amino acids and acylcarnitines levels. Here, we aimed to evaluate the association of circulating levels of amino acids and acylcarnitines with metabolic syndrome (MetS) and its components in Iranian adults. This cross-sectional study was performed on 1192 participants from the large-scale cross-sectional study of Surveillance of Risk Factors of non-communicable diseases (NCDs) in Iran (STEP 2016). The circulating levels of amino acids and acylcarnitines were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS) in individuals with MetS (n=529) and without MetS (n=663). The higher plasma levels of branched-chain amino acids (Val, Leu), aromatic amino acids (Phe, Tyr), Pro, Ala, Glu, and the ratio of Asp to Asn were significantly associated with MetS, whereas lower circulating levels of Gly, Ser, His, Asn, and citrulline were significantly associated with MetS. As for plasma levels of free carnitine and acylcarnitines, higher levels of short-chain acylcarnitines (C2, C3, C4DC), free carnitine (C0), and long-chain acylcarnitines (C16, C18OH) were significantly associated with MetS. Principal component analysis (PCA) showed that factor 3 (Tyr, Leu, Val, Met, Trp, Phe, Thr) [OR:1.165, 95% CI: 1.121-1.210, P
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2023.1058952