Intelligent tunable CAR-T cell therapy leads the new trend

Adoptive transfer of T cells engineered with chimeric antigen receptor (CAR) has been proved to have robust anti-tumor effects against hematological malignancies. However, problems about safety and efficacy, such as cytokine release syndrome (CRS), T cell exhaustion and antigen escape are still rais...

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Bibliographic Details
Published in:Synthetic and systems biotechnology 2023-12, Vol.8 (4), p.606-609
Main Authors: Cheng, Jiayi, Liu, Mingyao, Zhang, Jiqin
Format: Article
Language:English
Subjects:
Autologous universal system
Chimeric antigen receptor T
On and off systems
Review
Safety and efficacy
Synthetic notch system
Tumor
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Summary:Adoptive transfer of T cells engineered with chimeric antigen receptor (CAR) has been proved to have robust anti-tumor effects against hematological malignancies. However, problems about safety and efficacy, such as cytokine release syndrome (CRS), T cell exhaustion and antigen escape are still raised when patients are treated with CAR-T cells. Moreover, CAR-T therapy has limited applications in treating solid tumors, owing to inefficient infiltration and poor functional persistence of CAR-T cells and diverse immunosuppression in tumor microenvironment. In order to overcome these limitations and broad its applications, multiple controllable CAR-T technologies were exploited. In this article, we review the designs of intelligent controlled CAR-T technologies and the innovations that they bring about in recent years.
ISSN:2405-805X
2405-805X
DOI:10.1016/j.synbio.2023.09.001