Occupational and Environmental Cholangiocarcinoma-Related Toxic Exposures

Cholangiocarcinoma (CCA) is a malignancy that originates from the epithelial cells of the biliary system. Despite advancements in medical diagnostic techniques, CCAs remain a challenge to detect due to their silent clinical progression, making it difficult to diagnose these diseases. There are sever...

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Bibliographic Details
Published in:GE Portuguese journal of gastroenterology 2024-11, p.1-10
Main Authors: She, Tianyu, Shah, Nairuti, Jacob, Benna, Starkman, Nathan, Lieman, Julie, Kaur, Amandeep, Shah, Neal, Wilkenfeld, Marc
Format: Article
Language:English
Subjects:
cholangiocarcinoma
colangiocarcinoma
exposições ocupacionais
exposições tóxicas
extra-hepáticas
extrahepatic cholangiocarcinoma
intra-hepáticas
intrahepatic cholangiocarcinoma
occupational exposures
toxic exposures
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Summary:Cholangiocarcinoma (CCA) is a malignancy that originates from the epithelial cells of the biliary system. Despite advancements in medical diagnostic techniques, CCAs remain a challenge to detect due to their silent clinical progression, making it difficult to diagnose these diseases. There are several well-established risk factors for CCA, including biliary tract infection and inflammation. However, there is also growing evidence that community and occupational exposures play a significant role in the development of bile duct cancers. This review examines the geographical distribution of these risk factors and the importance of surveillance in individuals exposed to these toxins who are more prone to developing CCA.
ISSN:2341-4545
2387-1954
DOI:10.1159/000541868