Characterization and Biological Evaluation of Propolis from Poland

In this study, we assessed the therapeutic potential of propolis from Poland and performed chemical analysis by GC-MS, as well as determined its botanical origin. Chemical constituents typical for bud exudates of (section ) were determined, however, glycerol esters of phenolic acids, as well as unus...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2017-07, Vol.22 (7), p.1159
Main Authors: Popova, Milena, Giannopoulou, Efstathia, Skalicka-Woźniak, Krystyna, Graikou, Konstantia, Widelski, Jaroslaw, Bankova, Vassya, Kalofonos, Haralabos, Sivolapenko, Gregory, Gaweł-Bęben, Katarzyna, Antosiewicz, Beata, Chinou, Ioanna
Format: Article
Language:English
Subjects:
Analytical chemistry
Anti-Bacterial Agents - chemistry
Antibacterial activity
Antibacterial materials
Antifungal activity
Antifungal Agents - chemistry
Antimicrobial agents
Antineoplastic Agents - chemistry
Cancer
Cell Line, Tumor
Chemical analysis
Constituents
Coumaric Acids - chemistry
cytotoxic activity
Dichloromethane
Esters
Exudates
Exudation
Ferulic acid
Flavonoids
Fungicides
Gas Chromatography-Mass Spectrometry
GC–MS
Glycerol
Humans
Hydroxybenzoates - chemistry
Laboratories
Minimum inhibitory concentration
Natural products
Organic chemistry
Pharmacy
Phenolic acids
Phenols
Poland
Polish propolis
Populus nigra
Populus tremula
Propolis
Propolis - chemistry
Tumor cell lines
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Summary:In this study, we assessed the therapeutic potential of propolis from Poland and performed chemical analysis by GC-MS, as well as determined its botanical origin. Chemical constituents typical for bud exudates of (section ) were determined, however, glycerol esters of phenolic acids, as well as unusually high amounts of -coumaric and ferulic acid and their benzyl esters, were also detected. These constituents are characteristic for buds of (section ). We also evaluated the antiproliferative effect of propolis extracts against nine human cancer cell lines. Additionally, promising antibacterial activity of the dichloromethane extract (Minimal Inhibitory Concentration MIC values of 0.95-1.24 mg/mL), as well as a moderate antifungal activity (MIC values of 1.25-1.40 mg/mL), was noticed. Propolis from Poland appeared as a rich source of antibacterial and antiproliferative compounds and this confirmed that it is a valuable natural product with the potential to improve human health.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules22071159