Standardized wireless deep brain stimulation system for mice

Deep brain stimulation (DBS) has emerged as a revolutionary technique for accessing and modulating brain circuits. DBS is used to treat dysfunctional neuronal circuits in neurological and psychiatric disorders. Despite over two decades of clinical application, the fundamental mechanisms underlying D...

Full description

Saved in:
Bibliographic Details
Published in:NPJ Parkinson's Disease 2024-08, Vol.10 (1), p.153-11
Main Authors: Grotemeyer, Alexander, Petschner, Tobias, Peach, Robert, Hoehl, Dirk, Knauer, Torsten, Thomas, Uwe, Endres, Heinz, Blum, Robert, Sendtner, Michael, Volkmann, Jens, Ip, Chi Wang
Format: Article
Language:English
Subjects:
692/617/375/1718
692/699/375/346/1718
Biomedical and Life Sciences
Biomedicine
Deep brain stimulation
Neurology
Neurosciences
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Deep brain stimulation (DBS) has emerged as a revolutionary technique for accessing and modulating brain circuits. DBS is used to treat dysfunctional neuronal circuits in neurological and psychiatric disorders. Despite over two decades of clinical application, the fundamental mechanisms underlying DBS are still not well understood. One reason is the complexity of in vivo electrical manipulation of the central nervous system, particularly in rodent models. DBS-devices for freely moving rodents are typically custom-designed and not commercially available, thus making it difficult to perform experimental DBS according to common standards. Addressing these challenges, we have developed a novel wireless microstimulation system for deep brain stimulation (wDBS) tailored for rodents. We demonstrate the efficacy of this device for the restoration of behavioral impairments in hemiparkinsonian mice through unilateral wDBS of the subthalamic nucleus. Moreover, we introduce a standardized and innovative pipeline, integrating machine learning techniques to analyze Parkinson’s disease-like and DBS-induced gait changes.
ISSN:2373-8057
2373-8057
DOI:10.1038/s41531-024-00767-2