Enhancing Plasticity of the Central Nervous System: Drugs, Stem Cell Therapy, and Neuro-Implants

Stroke represents the first cause of adult acquired disability. Spontaneous recovery, dependent on endogenous neurogenesis, allows for limited recovery in 50% of patients who remain functionally dependent despite physiotherapy. Here, we propose a review of novel drug therapies with strong potential...

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Bibliographic Details
Published in:Journal of neural transplantation & plasticity 2017-01, Vol.2017 (2017), p.1-9
Main Authors: Loubinoux, Isabelle, Vaysse, Laurence, Vieu, Christophe, Demain, Boris, Davoust, Carole, Salabert, Anne-Sophie, Le Friec, Alice, Payoux, Pierre
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials
Biological products
Biomarkers
Brain - drug effects
Brain - pathology
Brain damage
Drug dosages
Drugs
Growth factors
Humans
Life Sciences
Nanotechnology
Nervous system
Neurogenesis
Neuronal Plasticity
Neurons and Cognition
Neuroprotective Agents
Physical therapy
Recovery of Function
Review
Spinal cord
Stem Cell Transplantation
Stem cells
Stroke
Stroke - drug therapy
Stroke - therapy
Stroke Rehabilitation - methods
Therapeutics, Physiological
Transplantation
Transplants & implants
Traumatic brain injury
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Summary:Stroke represents the first cause of adult acquired disability. Spontaneous recovery, dependent on endogenous neurogenesis, allows for limited recovery in 50% of patients who remain functionally dependent despite physiotherapy. Here, we propose a review of novel drug therapies with strong potential in the clinic. We will also discuss new avenues of stem cell therapy in patients with a cerebral lesion. A promising future for the development of efficient drugs to enhance functional recovery after stroke seems evident. These drugs will have to prove their efficacy also in severely affected patients. The efficacy of stem cell engraftment has been demonstrated but will have to prove its potential in restoring tissue function for the massive brain lesions that are most debilitating. New answers may lay in biomaterials, a steadily growing field. Biomaterials should ideally resemble lesioned brain structures in architecture and must be proven to increase functional reconnections within host tissue before clinical testing.
ISSN:2090-5904
0792-8483
1687-5443
DOI:10.1155/2017/2545736