Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation

Pd-catalysed C-C bond formation is an essential tool within the pharmaceutical and agrochemical industries. Many of these reactions rely heavily on polar aprotic solvents; however, despite their utility, these solvents are incompatible with the drive towards more sustainable chemical synthesis. Here...

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Bibliographic Details
Published in:Beilstein journal of organic chemistry 2016-09, Vol.12 (1), p.2005-2011
Main Authors: Wilson, Kirsty L, Kennedy, Alan R, Murray, Jane, Greatrex, Ben, Jamieson, Craig, Watson, Allan J B
Format: Article
Language:English
Subjects:
Cacchi annulation
Chemistry
cross-coupling
Full Research Paper
heterocycles
Sonogashira
sustainable solvent
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Summary:Pd-catalysed C-C bond formation is an essential tool within the pharmaceutical and agrochemical industries. Many of these reactions rely heavily on polar aprotic solvents; however, despite their utility, these solvents are incompatible with the drive towards more sustainable chemical synthesis. Herein, we describe the scope and limitations of an alternative to DMF derived from renewable sources (Cyrene ) in Sonogashira cross-coupling and Cacchi-type annulations.
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.12.187