Integrated Approach to Evaluate the Association between Exposure to Pesticides and Idiopathic Premature Thelarche in Girls: The PEACH Project

Several pesticides are recognized as endocrine-disrupting chemicals (EDCs) since they can interfere with the dysregulation of sexual, thyroid and neuro-endocrine hormones. Children are particularly vulnerable to the adverse effects of EDCs due to their developmental stage, peculiar lifestyle and die...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-05, Vol.21 (9), p.3282
Main Authors: Coppola, Lucia, Tait, Sabrina, Ciferri, Lorella, Frustagli, Gianluca, Merola, Carmine, Perugini, Monia, Fabbrizi, Enrica, La Rocca, Cinzia
Format: Article
Language:English
Subjects:
Agriculture
Androgens
Breast cancer
Cell growth
Child
Children & youth
Data integration
dietary exposure
Dietary Exposure - statistics & numerical data
Dietary intake
Endocrine disruptors
Endocrine Disruptors - toxicity
Enzymes
Ethics
Evaluation
Exposure
Female
Food
Food intake
Herbicides
Homeostasis
Hormones
Humans
idiopathic premature thelarche
Integrated approach
Intensive farming
Metabolism
Metabolites
Pesticide residues
Pesticides
Pesticides - toxicity
Project Report
Puberty
Puberty, Precocious - epidemiology
Risk analysis
Risk factors
Studies
Thyroid
Thyroid gland
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Summary:Several pesticides are recognized as endocrine-disrupting chemicals (EDCs) since they can interfere with the dysregulation of sexual, thyroid and neuro-endocrine hormones. Children are particularly vulnerable to the adverse effects of EDCs due to their developmental stage, peculiar lifestyle and dietary habits. In this context, the exposure to pesticides represents an important risk factor associated with early development. This study deals with the possible association between exposure to pesticides and idiopathic premature thelarche in girls from areas of intensive agriculture practice in the Centre of Italy. An integrated approach was set up, including: (i) a case-control study on girls with idiopathic premature thelarche; (ii) the evaluation of multiple pesticides exposure in girls; (iii) the evaluation of multiple pesticides in food; (iv) the dietary intake of pesticide residues; (v) the assessment of toxicological effects of widely used pesticides by in vitro model. Data integration will provide an estimate of the predictive risk of potential effects on girls' health, linked to dietary intake.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21093282