Observation on the therapeutic effect of probiotics on early oral feeding in the treatment of severe acute pancreatitis

To evaluate the clinical efficacy of probiotics and early oral feeding in patients with severe acute pancreatitis. A prospective, randomized, controlled trial was conducted involving 66 patients, who were randomly divided into a control group (  = 32) receiving standard enteral nutrition and an obse...

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Bibliographic Details
Published in:Frontiers in medicine 2024, Vol.11, p.1492108
Main Authors: Zhao, Yanan, Zhang, Rui, Wang, Shuling, Yang, Chunchun, Wang, Yang, Fan, Hongyun, Yang, Mingyue
Format: Article
Language:English
Subjects:
enteral nutrition
inflammation
Medicine
pancreatitis
probiotics
treatment outcome
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Summary:To evaluate the clinical efficacy of probiotics and early oral feeding in patients with severe acute pancreatitis. A prospective, randomized, controlled trial was conducted involving 66 patients, who were randomly divided into a control group (  = 32) receiving standard enteral nutrition and an observation group (  = 34) receiving additional Bifidobacterium quadruplex live bacterial tablets. Serum inflammatory markers, including white blood cells (WBC), interleukin-6 (IL-6), tumor necrosis factor- (TNF-α), and C-reactive protein (CRP), were measured on days 1, 3, and 7 post-admission. Abdominal pain scores, the computed tomography severity index (CTSI), and the Bedside Index for Severity in Acute Pancreatitis (BISAP) scores were also assessed. Additionally, defecation time and the total duration of hospitalization were compared between the two groups. Inflammatory markers declined in all groups by the third day post-admission, with the observation group exhibiting a significantly greater reduction compared to the control group (  
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2024.1492108