Inhibition by Selenium Compounds of Catecholamine Secretion Due to Inhibition of Ca2+ Influx in Cultured Bovine Adrenal Chromaffin Cells

Selenium is an essential trace metal element, whereas large doses of selenium exert adverse effects to the human body. We examined the effects of selenium compounds, sodium selenite (Na2SeO3) and sodium selenate (Na2SeO4), on catecholamine secretion from cultured bovine adrenal chromaffin cells. Tre...

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Published in:Journal of Pharmacological Sciences 2006, Vol.101(3), pp.223-229
Main Authors: Yasuhito, Uezono, Yumiko, Toyohira, Nobuyuki, Yanagihara, Akihiko, Wada, Kohtaro, Taniyama
Format: Article
Language:English
Subjects:
adrenal chromaffin cell
Adrenal Medulla - cytology
Adrenal Medulla - drug effects
Adrenal Medulla - metabolism
Animals
Calcium - metabolism
Carbachol - pharmacology
catecholamine secretion
Catecholamines - metabolism
Cattle
Cell Survival
Cells, Cultured
Chromaffin Cells - drug effects
Chromaffin Cells - metabolism
Dose-Response Relationship, Drug
ion flux
Potassium - pharmacology
Selenic Acid
Selenium Compounds - pharmacology
Selenium Compounds - toxicity
Sodium - metabolism
sodium selenite
Sodium Selenite - pharmacology
Sodium Selenite - toxicity
Time Factors
trace metal
Veratridine - pharmacology
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Summary:Selenium is an essential trace metal element, whereas large doses of selenium exert adverse effects to the human body. We examined the effects of selenium compounds, sodium selenite (Na2SeO3) and sodium selenate (Na2SeO4), on catecholamine secretion from cultured bovine adrenal chromaffin cells. Treatment of chromaffin cells with sodium selenite for 72, 48, and 24 h caused decreases in protein and catecholamine contents, in association with cell damage, at concentrations over 30, 300, and 300 µM, respectively. The cells treated with subtoxic conditions (
ISSN:1347-8613
1347-8648
DOI:10.1254/jphs.FP0060204