A Randomized Control Trial of 3 IU IV Oxytocin Bolus with 7 IU Oxytocin Infusion versus 10 IU Oxytocin Infusion During Cesarean Section for Prevention of Postpartum Hemorrhage

Oxytocin is the preferred choice for prophylaxis and treatment of postpartum hemorrhage. Intravenous infusion has been a widely accepted route for Oxytocin administration. However, intravenous bolus route is not a readily preferred route due to apprehensions regarding hypotension that it may cause....

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Bibliographic Details
Published in:International journal of women's health 2020-01, Vol.12, p.1091-1097
Main Authors: Yaliwal, Rajasri G, Biradar, Aruna M, Dharmarao, Prathibha S, Kori, Shreedevi S, Mudanur, Subhashchandra R, Patil, Neelamma G, Shiragur, Shobha S, Mathapati, Sangamesh S
Format: Article
Language:English
Subjects:
blood loss
Blood pressure
Blood tests
Blood transfusion
Bupivacaine
Care and treatment
Cesarean section
Childbirth & labor
Drug dosages
General anesthesia
Gynecology
Heart rate
Hemodynamics
Hemoglobin
Hemoglobins
Hemorrhage
Hypotension
Obstetrics
Original Research
Oxytocics
oxytocin
Pregnant women
Prevention
Standard deviation
uterine tone
Uterus
Vagina
Womens health
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Summary:Oxytocin is the preferred choice for prophylaxis and treatment of postpartum hemorrhage. Intravenous infusion has been a widely accepted route for Oxytocin administration. However, intravenous bolus route is not a readily preferred route due to apprehensions regarding hypotension that it may cause. This trial compares low dose 3 IU intravenous (IV) bolus Oxytocin along with 7 IU Oxytocin in intravenous infusion to 10IU Oxytocin intravenous infusion during cesarean section. A total of 250 term pregnant women were randomized to either 3 IU intravenous bolus with 7 IU intravenous infusion of Oxytocin or 10IU of intravenous Oxytocin infusion. The difference in pre- and post-operative hemoglobin levels, tone of the uterus, hemodynamic changes, adverse effects of the drug, need for additional uterotonics and need for blood transfusions were assessed. There was 6.7% less blood loss in the 3 IU IV bolus Oxytocin with 7 IU Oxytocin infusion group in comparison to the Oxytocin infusion group. The tone of the uterus was firmer in IV bolus Oxytocin with Oxytocin infusion group at 5 minutes (p
ISSN:1179-1411
1179-1411
DOI:10.2147/IJWH.S280842