Advanced Strategies for 3D Bioprinting of Tissue and Organ Analogs Using Alginate Hydrogel Bioinks

Alginate is a natural polysaccharide that typically originates from various species of algae. Due to its low cost, good biocompatibility, and rapid ionic gelation, the alginate hydrogel has become a good option of bioink source for 3D bioprinting. However, the lack of cell adhesive moieties, erratic...

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Bibliographic Details
Published in:Marine drugs 2021-12, Vol.19 (12), p.708
Main Authors: Gao, Qiqi, Kim, Byoung-Soo, Gao, Ge
Format: Article
Language:English
Subjects:
3-D printers
3D bioprinting strategy
Algae
alginate hydrogel
Alginates
Alginates - chemistry
Alginic acid
Analogs
Animals
Biocompatibility
Biodegradability
Biodegradation
bioink formulation
biomedical applications
Biomedical materials
Bioprinting
Hydrogels
Hydrogels - chemistry
Ink jet printers
Polysaccharides
Printing, Three-Dimensional
Review
Seaweed meal
Three dimensional printing
Tissue
Tissue Engineering
Tissue Scaffolds - chemistry
Tissues
Viscosity
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Summary:Alginate is a natural polysaccharide that typically originates from various species of algae. Due to its low cost, good biocompatibility, and rapid ionic gelation, the alginate hydrogel has become a good option of bioink source for 3D bioprinting. However, the lack of cell adhesive moieties, erratic biodegradability, and poor printability are the critical limitations of alginate hydrogel bioink. This review discusses the pivotal properties of alginate hydrogel as a bioink for 3D bioprinting technologies. Afterward, a variety of advanced material formulations and biofabrication strategies that have recently been developed to overcome the drawbacks of alginate hydrogel bioink will be focused on. In addition, the applications of these advanced solutions for 3D bioprinting of tissue/organ mimicries such as regenerative implants and in vitro tissue models using alginate-based bioink will be systematically summarized.
ISSN:1660-3397
1660-3397
DOI:10.3390/md19120708