From MAFLD to hepatocellular carcinoma and everything in between

Metabolic (dysfunction) associated fatty liver disease (MAFLD), previously known as non-alcoholic fatty liver disease, is the most common cause of chronic liver disease worldwide. Many risk factors contribute to the pathogenesis of MAFLD with metabolic dysregulation being the final arbiter of its de...

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Bibliographic Details
Published in:Chinese medical journal 2022-03, Vol.135 (5), p.547-556
Main Authors: Bae, Sarah Da Won, George, Jacob, Qiao, Liang
Format: Article
Language:English
Subjects:
African Americans
Age groups
Body mass index
Carcinoma, Hepatocellular - complications
Diabetes
Epidemiology
Estrogens
Health risk assessment
Humans
Lipids
Liver cancer
Liver diseases
Liver Neoplasms - complications
Males
Metabolism
Mortality
Non-alcoholic Fatty Liver Disease - complications
Obesity
Overweight
Pediatrics
Population
Review
Risk Factors
Teenagers
Womens health
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Summary:Metabolic (dysfunction) associated fatty liver disease (MAFLD), previously known as non-alcoholic fatty liver disease, is the most common cause of chronic liver disease worldwide. Many risk factors contribute to the pathogenesis of MAFLD with metabolic dysregulation being the final arbiter of its development and progression. MAFLD poses a substantial economic burden to societies, which based on current trends is expected to increase over time. Numerous studies have addressed various aspects of MAFLD from its risk associations to its economic and social burden and clinical diagnosis and management, as well as the molecular mechanisms linking MAFLD to end-stage liver disease and hepatocellular carcinoma. This review summarizes current understanding of the pathogenesis of MAFLD and related diseases, particularly liver cancer. Potential therapeutic agents for MAFLD and diagnostic biomarkers are discussed.
ISSN:0366-6999
2542-5641
DOI:10.1097/CM9.0000000000002089